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http://dx.doi.org/10.3746/jkfn.2014.43.1.067

Anticancer Effects of Cultivated Orostachys japonicus on Human Prostate Cancer Cells  

Won, Yeong Seon (Dept. Food and Nutrition, Sunchon National University)
Lee, Ju Hye (Research Institute of Basic Science, Sunchon National University)
Kwon, Soon Jae (Dept. of Food Science and Technology, Kyungpook National University)
Ahn, Dong Uk (Dept. of Animal Science, Iowa State University)
Shin, Dong Young (Dept. of Development in Resource Plants, Sunchon National University)
Seo, Kwon Il (Dept. Food and Nutrition, Sunchon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.43, no.1, 2014 , pp. 67-73 More about this Journal
Abstract
This study was performed to determine the anticancer effects of cultivated Orostachys japonicus (COJ) and wild Orostachys japonicus (WOJ) on primary human prostate cancer cells (RC-58T/h/SA#4 cells). The morphology of cells treated with COJ and WOJ was distorted to shrunken cell masses. In addition, cell death induced by COJ and WOJ was associated with increased population of cells in sub-G1 phase as well as the formation of apoptotic bodies and nuclear condensation. COD and WOJ markedly reduced the number of viable prostate cancer cells in a dose-dependent manner, and cell numbers were lower than control cells. COJ and WOJ also inhibited increases in cell proliferation induced by environmental hormones such as dioxin and bisphenol A in charcoal-treated FBS (cFBS) medium. COJ and WOJ methanol extracts at the tested concentrations (150, 300, and 600 ${\mu}g/mL$) also dose-dependently inhibited cell proliferation induced by environmental hormones. These results indicate that COJ and WOJ exert anticancer effects on primary human prostate cancer cells.
Keywords
cultivated Orostachys japonicus; anticancer activity; apoptosis; environmental hormone;
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Times Cited By KSCI : 15  (Citation Analysis)
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