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http://dx.doi.org/10.3746/jkfn.2013.42.5.670

Effects of Acorn Powder on Lifespan and a Resistance to Oxidative Stress in Caenorhabditis elegans  

Lee, Soon-Young (Dept. of Medical Biotechnology, College of Medical Sciences, Soonchunhyang University)
Lee, Jin-Sun (Dept. of Medical Biotechnology, College of Medical Sciences, Soonchunhyang University)
Park, Sang-Kyu (Dept. of Medical Biotechnology, College of Medical Sciences, Soonchunhyang University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.42, no.5, 2013 , pp. 670-674 More about this Journal
Abstract
The free radical theory of aging suggests that oxidative damage caused by free radicals plays a key role in normal aging. We measured the anti-oxidant activity of acorns and asked whether it can modulate the aging process in Caenorhabditis elegans. Different concentrations of acorn powder were added to culture medium, followed by the monitoring of fertility and survival under oxidative stress. The anti-oxidant activity of 500 mg/L of acorn powder exhibited significant increases in the resistance to oxidative stress in vivo. Acorn powder also significantly extended both the mean and maximum lifespan of C. elegans (the mean lifespan was increased up to 22.4%). The fertility assay indicates the lifespan extension from acorn does not accompany a reduced reproduction, which is common in long-lived mutants. These findings indicate that acorn has a strong antioxidant activity and can induce longevity without the trade-off of reduced reproduction in C. elegans.
Keywords
acorn; oxidative stress; lifespan; fertility; Caenorhabditis elegans;
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1 Honda Y, Fujita Y, Maruyama H, Araki Y, Ichihara K, Sato A, Kojima T, Tanaka M, Nozawa Y, Ito M, Honda S. 2011. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One 6: e23527.   DOI
2 Kitani K, Yokozawa T, Osawa T. 2004. Interventions in aging and age-associated pathologies by means of nutritional approaches. Ann N Y Acad Sci 1019: 424-426.   DOI   ScienceOn
3 Hughes SE, Evason K, Xiong C, Kornfeld K. 2007. Genetic and pharmacological factors that influence reproductive aging in nematodes. PLoS Genet 3: e25.   DOI   ScienceOn
4 Larsen PL, Albert PS, Riddle DL. 1995. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139: 1567-1583.
5 Gems D, Sutton AJ, Sundermeyer ML, Albert PS, King KV, Edgley ML, Larsen PL, Riddle DL. 1998. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150: 129-155.
6 Min KJ, Lee CK, Park HN. 2012. The lifespan of Korean eunuchs. Current Biology 22: R792-R793.   DOI   ScienceOn
7 Wei YH, Lee HC. 2002. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp Biol Med (Maywood) 227: 671-682.   DOI
8 Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.   DOI   ScienceOn
9 Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. 2004. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689.   DOI   ScienceOn
10 Lakshmanan AP, Watanabe K, Thandavarayan RA, Sari FR, Meilei H, Soetikno V, Arumugam S, Giridharan VV, Suzuki K, Kodama M. 2011. Curcumin attenuates hyperglycaemia- mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat. Free Radic Res 45: 788-795.   DOI   ScienceOn
11 Sreejayan N, Rao MN. 1996. Free radical scavenging activity of curcuminoids. Arzneimittelforschung 46: 169-171.
12 Fukui K, Omoi NO, Hayasaka T, Shinnkai T, Suzuki S, Abe K, Urano S. 2002. Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Ann N Y Acad Sci 959: 275-284.   DOI
13 Park SK, Page GP, Kim K, Allison DB, Meydani M, Weindruch R, Prolla TA. 2008. ${\alpha}$- and ${\gamma}$-tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. J Nutr 138: 1010-1018.   DOI
14 Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA. 2004. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med 36: 1043-1057.   DOI   ScienceOn
15 Rosenfeldt FL, Pepe S, Linnane A, Nagley P, Rowland M, Ou R, Marasco S, Lyon W, Esmore D. 2002. Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients. Ann N Y Acad Sci 959: 355-359.   DOI
16 Lee JM, Kim SH. 2008. Antioxidant properties of acorn hotwater extract using response surface methodology. Korean J Food Preserv 15: 111-117.
17 Ryu HS. 2010. Effects of water extract acorn on mouse immune cell activation ex vivo. Korean J Food & Nutr 23:135-140.   과학기술학회마을
18 Kim BN. 1995. A study on the literature review of acorn in Korea. Korea J Soc Food Sci 11: 158-163.   과학기술학회마을
19 Lee SH, Kim DI, Cho SY, Jung HJ, Cho SM, Park HJ, Lillehoj HS. 2005. Effects of acorn (Quercus acutissima CARR.) supplementation on the level of acetylcholine and its related enzyme activities in the brain of dementia mouse model. J Korean Soc Food Sci Nutr 34: 738-742.   과학기술학회마을   DOI   ScienceOn
20 Sung IS, Park EM, Lee MK, Han EK, Jang JY, Cho SY. 1997. Effect of acorn extracts on the antioxidative enzyme system. J Korean Soc Food Sci Nutr 26: 494-500.
21 Peto R, Peto J. 1972. Asymptotically efficient rank invariant test procedures. J R Statist Soc A 135: 185-207.   DOI   ScienceOn
22 Herman D. 1956. Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298-300.   DOI   ScienceOn
23 Sohal RS, Weindruch R. 1996. Oxidative stress, caloric restriction, and aging. Science 273: 59-63.   DOI   ScienceOn
24 Beckman KB, Ames BN. 1998. The free radical theory of aging matures. Physiol Rev 78: 547-581.   DOI
25 Sohal RS, Agarwal A, Agarwal S, Orr WC. 1995. Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster. J Biol Chem 270: 15671-15674.   DOI   ScienceOn
26 Miquel J. 2001. Nutrition and ageing. Public Health Nutrition 4: 1385-1388.