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http://dx.doi.org/10.3746/jkfn.2013.42.4.563

Dose-Response of Chitooligosaccharide on Gut Ecology and Lipid Status in Rats  

Kim, Yeon-Rok (Dept. of Food and Nutrition, Daegu University)
Choi, Young-Sun (Dept. of Food and Nutrition, Daegu University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.42, no.4, 2013 , pp. 563-569 More about this Journal
Abstract
This study was carried out to investigate the dose-response of chitooligosaccharide (with a molecular weight of 1~3 kDa) on antimicrobial activity and lipid lowering functions in rats. Sprague-Dawley male rats were given experimental diets containing 0 (control), 0.5, 2, or 5% chitooligosaccharide (COS) for 5 weeks. Weight gain and food intake were significantly lower in rats fed 5% COS than control rats and rats fed 0.5 and 2% COS. The numbers of fecal bacteria, including bifidobacteria, lactobacilli, bacteroides, total anaerobes, and total aerobes, which reflect gut microbiota, were significantly decreased in rats fed 5% COS. Plasma triglyceride concentrations significantly decreased in a dose-dependent manner in rats fed 2% or 5% COS, while plasma total cholesterol was not significantly different among groups. The hepatic concentration of triglycerides was lower in rats fed 5% COS, and fecal triglycerides significantly increased in rats fed 5% COS. These results indicate that 5% COS supplementation in a diet may exert antimicrobial activity in vivo, and inhibit the proliferation of typical gut microbes, while lowering lipids.
Keywords
chitooligosaccharide; antimicrobial activity; fecal microbes; plasma lipids;
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Times Cited By KSCI : 6  (Citation Analysis)
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