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http://dx.doi.org/10.3746/jkfn.2013.42.3.384

Anti-Inflammatory Effects of Extracts from Caesalpinia sappan L. on Skin Inflammation  

Eum, Won Sik (Dept. of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University)
Lee, Kwang-Jae (Gangwon Agricultural Research and Extention Services)
Kim, Dae Won (Dept. of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University)
Lim, Soon Sung (Dept. of Food Sciences and Nutrition and RIC Center, Hallym University)
Kang, Il-Jun (Dept. of Food Sciences and Nutrition and RIC Center, Hallym University)
Park, Jinseu (Dept. of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University)
Choi, Soo Young (Dept. of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.42, no.3, 2013 , pp. 384-388 More about this Journal
Abstract
This study investigated the anti-inflammatory effects of extracts from Caesalpinia sappan L. (CSL) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. Skin inflammation was detected by immunohistochemistry and the protein and mRNA expression levels of cyclooxygenase-2 (COX-2) and cytokines (IL-6, IL-$1{\beta}$ and TNF-${\alpha}$) detected by Western blotting and RT-PCR. The activation of nuclear factor-kappa B (NF-${\kappa}B$) and mitogen-activated protein kinase (MAPK) were analyzed by Western blotting. CSL extracts markedly inhibited the TPA-induced expression of COX-2 and pro-inflammatory cytokines. Also, CSL extracts significantly reduced the activation of NF-${\kappa}B$ and MAPK. These results suggest that CSL extracts may serve as therapeutic agents against skin diseases related to inflammation.
Keywords
inflammation; TPA; Caesalpinia sappan L.; NF-${\kappa}B$; MAPK;
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