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http://dx.doi.org/10.3746/jkfn.2012.41.8.1072

Antioxidant and Anti-inflammatory Effect of Extracts from Flammulina velutipes (Curtis) Singer  

Kang, Hyun-Woo (Dept. of Korean Food & Culinary Arts, Youngsan University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.8, 2012 , pp. 1072-1078 More about this Journal
Abstract
The potential antioxidant and anti-inflammatory effect of water and ethanol extracts from Flammulina velutipes (Curtis) Singer (FVS) on hydrogen peroxide ($H_2O_2$) and LPS-induced oxidative damage in PC-12 and RAW264.7 cells were investigated. The DPPH radical scavenging activities of the water extract from FVS was the highest, and the 50% inhibitory concentration value was 0.388 mg/mL. Also, the antioxidant activities of water and ethanol extracts were determined by ferric reducing antioxidant power, 2,2'-azino-bis-(3-ethybenzothiazoline-6-sulphonic acid) radical scavenging activity. In addition, water extract from FVS showed a strongly inhibitory effect on lipid peroxidation by measuring ferric thiocyanate values. The water extract decreased cell apoptosis in PC-12 cells against $H_2O_2$-induced oxidative damage. In addition, FVS extracts exhibited the strongest nitric oxide (NO) inhibition activity. It was also found that FVS extract inhibited LPS-induced iNOS and COX-2 expression in RAW264.7 cells. The findings of the present study suggest that extracts of FVS exhibit anti-oxidative and anti-inflammatory activity against oxidative stress and/or stimulated cells.
Keywords
antioxidant; anti-inflammation; Flammulina velutipes (Curtis) Singer; hydrogen peroxide;
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