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http://dx.doi.org/10.3746/jkfn.2012.41.7.943

Effect of Diets with Job's Tears and Cudrania tricuspidata Leaf Mixed-powder Supplements on Body Fat and Serum Lipid Levels in Rats Fed a High-Fat Diet  

Park, Ju-Hun (Korea Food Research Institute)
Lee, Kyoung-Won (Korea Food Research Institute)
Sung, Ki-Seung (Korea Food Research Institute)
Kim, Sung-Soo (Korea Food Research Institute)
Cho, Kyung-Dong (Food One Tech Inc.)
Lee, Bog-Hieu (Dept. of Food and Nutrition, Food Science and Technology, Chung-Ang University)
Han, Chan-Kyu (Korea Food Research Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.7, 2012 , pp. 943-949 More about this Journal
Abstract
This study investigated the effects of diets with a supplement of Job's tears (JT) and Cudrania tricuspidata leaf (CTL) powder as a functional food ingredient on obesity and lipid profiles in diet-induced obese rats. Male Sprague-Dawley rats were fed a high-fat diet (D12492, 45 kcal fat) for 5 weeks during the first phase. In the second phase, which lasted 5 weeks, the rats were divided into four experimental groups. The groups were a high-fat diet group as a control (HFD), a high-fat diet with 10% JT powder supplement group (JT-10), a 10% CTL powder supplement group (CTL-10), and a 20% JT and CTL 1:1 mixed-powder supplement group (MIX-20). The adipose tissue (RFP, EFP) weights were significantly decreased in the CTL-10 and MIX-20 groups than in the HFD group (p<0.05). The fecal weight produced by the MIX-20 group was highest among all experimental groups (p<0.05), and it was significantly increased during the second phase compared to the first phase (p<0.05). The serum total cholesterol content was significantly decreased in the CTL-10 and MIX-20 groups, and the LDL-cholesterol content was significantly low in the JT-10 and MIX-20 groups than in the HFD group (p<0.05). The blood glucose levels were significantly decreased in all experimental diet supplement groups than in the HFD group (p<0.05). The findings show that a diet of mixed JT and CTL could improve lipid metabolism.
Keywords
Job's tears; Cudrania tricuspidata; body fat; fecal amount; serum lipid;
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Times Cited By KSCI : 15  (Citation Analysis)
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1 Kim SH, Kim NJ, Choi JS, Park JC. 1993. Determination of flavonoid by HPLC and biological activities from the leaves of Cudrania tricuspidata bureau. J Korean Soc Food Nutr 22: 68-72.   과학기술학회마을
2 Otlersen T, Vance B, Doorenbos NJ, Chang BL, EI-Feraly FS. 1977. The crystal structure of cudranone, 2,6,3'-trihydroxy-4-methoxy-2'-(3-methoxy-2-buternyl)-I, a new antimicrobial agent from Cudrania cochinchinensis. Acta Chem Scand 31: 434-436.
3 Chang CH, Lin CC, Hattori M, Namba T. 1994. Effects of anti-lipid peroxidation of Cudrania cochinchinensis var. gerontogea. J Ethnopharomacol 44: 179-185.
4 Joo HY, Lim KT. 2009. Protective effect of glycoprotein isolated from Cudrania tricuspidata on liver in CCl4-treated A/J mice. Korean J Food Sci Technol 41: 93-99.   과학기술학회마을
5 Asano N, Oseki K, Tomioka E, Kizu H, Matsui K. 1994. N-containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohyr Res 259: 243-255.   DOI   ScienceOn
6 Jang MJ, Rhee SJ. 2004. Hypoglycemic effects of pills made of mulberry leaves and silkworm powder in streptozotocin- induced diabetic rats. J Korean Soc Food Sci Nutr 33: 1611-1617.   과학기술학회마을   DOI
7 Jang MJ, Rhee SJ. 2004. Hypoglycemic effects of pills made of mulberry leaves and silkworm powder in streptozotocin- induced diabetic rats. J Korean Soc Food Sci Nutr 33: 1611-1617.   과학기술학회마을   DOI
8 Reeves PG, Nielsen FH, Fahey GC. 1993. AIN-93 purified diets for laboratory rodent: final report of the American Institute Nutrition ad hoc writing committee in the reformulation of the AIN-76A rodent diets. J Nutr 123: 1939-1951.   DOI
9 Matsumoto N, Okushio K, Hara Y. 1998. Effect of black tea polyphenols on plasma lipids in cholesterol-fed rats. J Nutr Sci Vitaminol 44: 337-342.   DOI
10 Lim SC. 2006. Effects of yullmoo (Coix lachryma-jobi var. mayuen stapf.) ext. on lipid lowering and serum glucose in hyperlipidemic rat. Korean J Plant Res 19: 126-129.
11 Lee JM, Lee SH, Lee JH, Lee E. 2006. Effects of Coix lachryma- jobi var. mayuen stapf. pharmacopuncture on plasma lipid composition and glucose in rat fed high fat diet. Kor J Acupuncture 23: 59-66.   과학기술학회마을
12 Oh UJ, Kim GP, Cho YW, Chung SH, Gu SJ. 1999. Effect of beverage containing extract from mulberry leaves on serum glucose and lipid levels in db/db mouse. Annual Meeting of Korean Soc Food Sci Technol, Seoul, Korea. p 430.
13 Kim SY, Lee WC, Kim HB, Kim AJ, Kim SK. 1998. Antihyperlipidemic effects of methanol extracts from mulberry leaves in cholesterol induced hyperlipidemia in rats. J Korean Soc Food Sci Nutr 27: 1217-1222.   과학기술학회마을
14 Takahashi M, Konno CH. 1986. Isolation and hypoglycemic activity of coixans A, B and C, glycans of Coix lachryma-jobi var. ma-yuen seeds. Planta Med 52: 64-65.   DOI
15 Chung SH, Yu JH, Kim EJ, Ryu KS. 1996. Blood glucose lowering effect of silkworm. Bull K H Pharma Sci 24: 95-100.
16 Kim SY, Ryu KS, Lee WC, Ku HO, Lee HS, Lee KR. 1999. Hypoglycemic effect of mulberry leaves with anaerobic treatment in alloxan-induced diabetic mice. Korean J Pharmacogn 30: 123-129.   과학기술학회마을
17 Kritchevsky D. 1976. Diet and atherosclerosis. Am J Pathol 84: 615-632.
18 Yoo SK, Kim MJ, Kim JW, Rhee SJ. 2002. Effects of YK-209 mulberry leaves on disaccharidase activites of small intestine and blood glucose-lowering in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 31: 1071-1077.   과학기술학회마을   DOI
19 Lee S, So S, Hwang E, Koo B, Han G, Ko S, Kim N. 2008. Effect of ginseng and herbal plant mixtures on anti-obesity in obese SD rat induced by high fat diet. J Korean Soc Food Sci Nutr 37: 437-444.   과학기술학회마을   DOI
20 Anderson JW, Deakins DA, Floore TL, Smith BM, Whitis SE. 1990. Dietary fiber and coronary heart disease. Crit Rev Food Sci Nutr 29: 95-147.   DOI   ScienceOn
21 Ministry of Health and Welfare. 2005. Year Book of Health and Welfare Statistics. Korea. p 51-77.
22 Park YH, Lee JS, Lee YJ. 1993. Distribution of serum lipid by age and the relation of serum lipid to degree of obesity and blood pressure in Korean adults. Kor J Lipidiology 3: 165-180.
23 Lee SW. 1992. Research on ancient Korea dietary life history in the East Asia. Hyangmoonsa, Seoul, Korea. p 122.
24 Jin KD. 1975. Studies on coix ma-yuen roman. J Kor Pharm Sci 5: 307-311.
25 Chung BS, Suzuki H, Hayakawa S, Kim JH, Nishizaawa Y. 1988. Studied on the plasma cholesterol-lowing component in coix. J Japan Food Technol 35: 618.   DOI
26 Park YJ, Lee YS. 1988. Effect of coix on plasma cholesterol and lipid metabolism in rats. Korean J Nutr 21: 88-98.   과학기술학회마을
27 Lee JE, Suh MH, Lee HG, Yang CB. 2002. Characteristics of Job's tear gruel by various mixing ratio, particle size and soaking time of Job's tear and rice flour. Korean J Soc Food Cookery Sci 18: 193-199.
28 Avram AS, Avram MM, James WD. 2005. Subcutanous fat in normal and diseased status: 2. Anatomy and physiology of white and brown adipose tissue. J Am Acad Dermatol 53: 671-683.   DOI
29 Han CK, Kim SS, Choi SY, Park JH, Lee BH. 2009. Effects of rice added with mulberry leaves and fruit on blood glucose, body fat and serum lipid levels in rats. J Korean Soc Food Sci Nutr 38: 1336-1341.   과학기술학회마을   DOI
30 Kim HK, Cho DW, Hahm YT. 2000. The effects of coix bran on lipid metabolism and glucose challenge in hyperlipidemic and diabetic rats. J Korean Soc Food Sci Nutr 29: 140-146.   과학기술학회마을
31 Cha JY, Kim HJ, Jun BS, Cho YS. 2000. Effect of water-extracted of leaves from Morus alba and Cudrania tricuspidata on the lipid concentrations of serum and liver in rats. J Korean Soc Appl Biol Chem 43: 303-308.   과학기술학회마을
32 Mc Dougall GJ, Morrison IM, Hillman JR. 1996. Plant cell walls dietary fibre: range, structure, processing and function. J Sci Food Agric 70: 133-150.   DOI
33 Mc Dougall GJ, Morrison IM, Hillman JR. 1996. Plant cell walls dietary fibre: range, structure, processing and function. J Sci Food Agric 70: 133-150.   DOI
34 Jang JY, Choi HY. 2003. Effects of Artemisia iwayomogi oligosaccharide on the blood lipids, abdominal adipose tissues and leptin levels in the obese rats. Korean J Nutr 36: 437-445.   과학기술학회마을
35 Jang JY, Choi HY. 2003. Effects of Artemisia iwayomogi oligosaccharide on the blood lipids, abdominal adipose tissues and leptin levels in the obese rats. Korean J Nutr 36: 437-445.   과학기술학회마을