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http://dx.doi.org/10.3746/jkfn.2012.41.6.774

Chlorogenic Acid Enhances Glucose Metabolism and Antioxidant System in High-fat Diet and Streptozotocin-induced Diabetic Mice  

Lee, Jin (Dept. of Food and Nutrition, Sunchon National University)
Seo, Kwon-Il (Dept. of Food and Nutrition, Sunchon National University)
Kim, Myung-Joo (Dept. of Hotel Cuisine, Suseong College)
Lee, Su-Jin (Dept. of Hotel Cuisine, Suseong College)
Park, Eun-Mi (Division of Bio-Applied Science, Sung Duck C. University)
Lee, Mi-Kyung (Dept. of Food and Nutrition, Sunchon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.6, 2012 , pp. 774-781 More about this Journal
Abstract
This study investigated dose-response effects of chlorogenic acid (CA) on glucose metabolism and the antioxidant system in streptozotocin (STZ)-induced diabetic mice with a high-fat diet (HFD). Male ICR mice were fed with a HFD (37% calories from fat) for 4 weeks prior to intraperitoneal injection with STZ (100 mg/kg body weight). Diabetic mice were supplemented with two doses of CA (0.02% and 0.05%, wt/wt) for 6 weeks. Both doses of CA significantly improved fasting blood glucose level, glucose tolerance and insulin tolerance without any changes in plasma insulin and C-peptide levels. Plasma leptin concentration was significantly higher in the CA-supplemented groups than in the diabetic control group. Both doses of CA significantly increased hepatic glucokinase activity and decreased glucose-6-phosphatase activity compared to the diabetic control group. The ratio of glucokinase/glucose-6-phosphatase was dose-independently higher in CA-supplemented mice than in diabetic control mice. CA supplementation dose-independently elevated superoxide dismutase and catalase activities, whereas it lowered lipid peroxide levels compared to the diabetic control mice in the liver and erythrocyte. These results suggest that low-dose CA may be used as a hypoglycemic agent in a high-fat diet and STZ-induced diabetic mice.
Keywords
chlorogenic acid; diabetes; high-fat diet; glucose metabolism; antioxidant system;
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