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http://dx.doi.org/10.3746/jkfn.2012.41.6.766

Effect of Diets with Mulberry Leaf and Cudrania tricuspidata Leaf Powder Supplements on Blood Glucose-Related Biomarkers in Streptozotocin-Induced Diabetic Rats  

Park, Ju-Hun (Korea Food Research Institute)
Lee, Kyoung-Won (Korea Food Research Institute)
Sung, Ki-Seung (Korea Food Research Institute)
Kim, Sung-Soo (Korea Food Research Institute)
Cho, Kyung-Dong (Food One Tech Inc.)
Lee, Bog-Hieu (Dept. of Food Science and Technology, Chung-Ang University)
Han, Chan-Kyu (Korea Food Research Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.6, 2012 , pp. 766-773 More about this Journal
Abstract
This study investigates the effects of diets with mulberry leaf and Cudrania tricuspidata leaf supplements on blood glucose-related biomarkers in streptozotocin-induced diabetic rats. Male diabetic Sprague-Dawley rats were divided into groups and fed several diets. Group A was fed a diet with a 10% supplement of mulberry leaves. Group B was fed a diet with a 10% supplement of mulberry leaves and an additional 10% supplement of Cudrania tricuspidata leaves. Group C was fed a diet with a 10% supplement of mulberry leaves and an additional 30% supplement of Cudrania tricuspidata leaves. Group D was fed a diet with a 10% supplement of Cudrania tricuspidata leaves. Group E was the DM control. All diets were based on AIN-93G diet and they all lasted 6 weeks. The blood glucose levels of groups B and C stayed similar to initial levels (reference blood glucose) for the experimental period, which was significantly lower than levels in groups A, D, and E at the 6th week (p<0.05). And the area under the blood glucose curve (AUC) was also significantly lower in groups B and C than in groups D and E (p<0.05). The fasting blood glucose level after the experiment was significantly lower in groups B and C (p<0.05), and the C-peptide content of group C was as high as 50 pmol/L on average. The HbA1c content was also significantly lower in groups A and B than in group E (p<0.05). The serum TG, AST, and ALT levels were significantly decreased in groups A, B, and D than in group E (p<0.05). From the findings, it is shown that a diet of 1:1 mulberry and Cudrania tricuspidata leaf supplements could improve blood glucose-related biomarkers.
Keywords
mulberry leaves; Cudrania tricuspidata; blood glucose; diabetic rats; triglyceride;
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Times Cited By KSCI : 11  (Citation Analysis)
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