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http://dx.doi.org/10.3746/jkfn.2012.41.5.605

The Effects of Sea Cucumber as an Anti-gastritis, Anti-gastric Ulcer, and Anti-Helicobater  

Oh, Hong-Geun (Huvet Co. Ltd.)
Moon, Dae-In (Huvet Co. Ltd.)
Kim, Jung-Hoon (Huvet Co. Ltd.)
Kang, Young-Rye (Huvet Co. Ltd.)
Park, Jung-Woo (Huvet Co. Ltd.)
Seo, Min-Young (Huvet Co. Ltd.)
Park, Sang-Hoon (Huvet Co. Ltd.)
Kang, Yang-Gyu (Heawon, Ltd.)
Choe, Chung-Hyeon (Jeonju Biomaterials Institute)
Park, In-Sun (Jeonju Biomaterials Institute)
Kim, Ju (Jeonju Biomaterials Institute)
Yu, Kang-Yeol (Jeonju Biomaterials Institute)
Seol, Eu-Ddeum (Center for Animal Resources Development, Wonkwang University)
Kim, Ok-Jin (Center for Animal Resources Development, Wonkwang University)
Lee, Hak-Yong (Huvet Co. Ltd.)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.5, 2012 , pp. 605-611 More about this Journal
Abstract
Sea cucumber, $Stichopus$ $japonicus$, is used not only as an outstanding tonic food but also as a traditional medicine for the treatment of asthma, hypertension, rheumatism, anemia, and sinus congestion. The purpose of this study was to examine sea cucumber as an anti-gastritis and anti-gastric ulcer in HCl-ethanol-induced gastric and $H.$ $pylori$-infected animal models. Thirty 7-week-old SD rats and Mongolian gerbils were divided into normal (Nor, n=6), control (Con, 60% HCl-ethanol+water, n=6), groupI (DSCI, 60% HCl-ethanol+sea cucumber 30 mg/kg, n=6), groupII (DSCII, 60% HCl-ethanol+sea cucumber 100 mg/kg, n=6), and group III (DSCIII, 60% HCl-ethanol+sea cucumber 300 mg/kg, n=6). Sea cucumber significantly suppressed gastric lesions and ulcers in the 60% HCl-ethanol-induced gastric model. Especially, 100 mg/kg of sea cucumber showed significantly inhibitory effects. In histopathological analysis of the $H.$ $pylori$ model, we found that sea cucumber augmented the eradication rates of $H.$ $pylori$ and attenuated gastric ulcer formation. Our results suggest that sea cucumber has inhibitory effects on gastritis and gastric ulcers. In addition, sea cucumber can be applied for the treatment of $H.$ $pylori$.
Keywords
sea cucumber; gastritis; gastric ulcer; Helicobacter pylori; HCl-ethanol;
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