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http://dx.doi.org/10.3746/jkfn.2012.41.4.443

Antioxidant Activities and Acetylcholinesterase Inhibitory Activities from Seaweed Extracts  

Jeon, Young-Eun (Dept. of Food Sciences and Nutrition, Hallym University)
Yin, Xing-Fu (Dept. of Food Sciences and Nutrition, Hallym University)
Lim, Soon-Sung (Dept. of Food Sciences and Nutrition, Hallym University)
Chung, Cha-Kwon (Dept. of Food Sciences and Nutrition, Hallym University)
Kang, Il-Jun (Dept. of Food Sciences and Nutrition, Hallym University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.4, 2012 , pp. 443-449 More about this Journal
Abstract
This study was conducted to investigate the antioxidant and acetylcholinesterase (AChE) inhibitory activities of extracts from various seaweed. The extracts of $Sargassum$ $thunbergii$ (91.3%), $Polysiphonia$ $morrowii$ (90.7%), $Ecklonia$ $cava$ (89.9%), and $Artemisia$ $fukudo$ (85.9%) showed over 80% high radical scavenging activities at the final concentration of 40 ${\mu}g$/mL. The $Artemisia$ $fukudo$ extract showed the highest inhibition activity of 30.2% on AChE at the final concentration of 10 ${\mu}g$/mL. The extract of $Porphyra$ $tenera$, $Costaria$ $costata$, $Monostroma$ $nitidum$, $Ecklonia$ $cava$, and $Agarum$ $clathratum$ against AChE at a concentration of 10 ${\mu}g$/mL exhibited inhibition of 26.6%, 25.3%, 23.4%, 21.7%, 20.4% and 19.9%, respectively. The bioautography results showed that the mixtures of structurally diverse compounds were thought to affect AChE inhibitory activity. These results suggest that extracts from seaweed with their high quality components may be effective in the prevention of Alzheimer's disease and may be used to develop various functional food products.
Keywords
seaweed; Alzheimer's disease; DPPH radical scavenging; acetylcholinesterase; TLC bioassay;
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