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http://dx.doi.org/10.3746/jkfn.2012.41.3.295

In vitro Evaluation of Biological Activities of Wa-song (Orostachys japonicus A. Berger) and Korean Traditional Plants Mixture  

Lee, Soo-Jung (Dept. of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University)
Shin, Jung-Hye (Namhae Garlic Research Institute)
Kang, Jae-Ran (Dept. of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University)
Hwang, Cho-Rong (Dept. of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University)
Sung, Nak-Ju (Dept. of Food Science and Nutrition, Institute of Agriculture and Life Sciences, Gyeongsang National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.3, 2012 , pp. 295-301 More about this Journal
Abstract
This study was carried out to determine the biological activities of Wa-song (Orostachys japonicus) hot water extracts. Four types of extract samples were prepared, including Wa-song, traditional plants mixture [PM; mixture of Baekbokryung (Poria cocos), Changchul (Atractylodis rhizoma), and Sa-in (Amomum xanthoides)], and two different ratio composites of these (mixture of PM and Wa-song extract, 1:1 (v/v); PMO-1 and 1:3 (v/v); PMO-3). Their biological activities were measured using various in vitro assays. Total phenolic and flavonoid contents of PM were higher compared to those of Wa-song, and those of PMO-1 were higher than those of PMO-3. Further, PMO-1 contained higher ABTS and DPPH radical scavenging, reducing power, and nitrite scavenging activities than PMO-3. On the contrary, PMO-3 contained higher tyrosinase and inhibitory activities of MCF-7 and HT-29 cancer cells than PMO-1. According to the results, biological activities of PMOs were significantly higher than those of Wa-song extract and PM in in vitro assays. Therefore, we expect that PMOs could show higher biological activities than Wa-song extract alone in vivo.
Keywords
Wa-song (Orostachys japonicus); plants mixture; antioxidant; anticancer activity;
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1 Park KJ, Jin HS, Park SH, Kim EH, Kim JK. 2008. Antihyperglycemia effect of medicinal plants mixture in streptozotocin- induced diabetic rats. J Korean Soc Food Sci Nutr 37: 1554-1559.   과학기술학회마을   DOI
2 Lee SJ, Seo JK, Shin JH, Lee HJ, Sung NJ. 2008. Antioxidant activity of Wa-song (Orostachys japonicus A. Berger) according to drying methods. J Korean Soc Food Sci Nutr 37: 605-611.   과학기술학회마을   DOI
3 Gutfinger T. 1981. Polyphenols in olive oil. J Am Oil Chem Soc 58: 966-968.   DOI   ScienceOn
4 Moreno MIN, Isla MI, Sampietro AR, Vattuone MA. 2000. Comparison of the free radical-scavenging activity of propolis from several region of Argentina. J Ethnopharmacol 71: 109-114.   DOI   ScienceOn
5 Re R, Pellegrini N, Pannala A, Yang M, Rice-Evans C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol Med 26: 1231-1237.   DOI   ScienceOn
6 Blois MS. 1958. Antioxidant determinations by the use of a stable free radical. Nature 181: 1199-1200.   DOI   ScienceOn
7 Oyaizu M. 1986. Studies on products of browning reactions: antioxidative activities of products of browning reaction prepared from glucosamine. J apanese J Nutr 44: 307-315.   DOI
8 Kim DS, Ahn BW, Yeum DM, Lee DW, Kim ST, Park YH. 1987. Degradation of carcinogenic nitrosamine formation factor by natural food components. Bull Korean Fish Soc 20: 463-468.   과학기술학회마을
9 Yagi A, Kanbara T, Morinobu N. 1986. The effect of tyrosinase inhibition for aloe. Planta Med 3981: 517-519.
10 Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: applicaton to proliferation and cytotoxicity assays. J Immunol Meth 65: 55-63.   DOI   ScienceOn
11 Jung HJ, Choi J, Nam JH, Park HJ. 2007. Antiulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice. J Med Food 10: 702-706.   DOI   ScienceOn
12 Kang AS, Kang TS, Shon SM, Kang MS, Kim GP, Lee JS. 1999. Studies on improvement of artificial cultivation and antioxidative activity of Poria cocos. Korean J Mycol 27: 378-380   과학기술학회마을
13 Kwon MS, Chung SK, Choi JU, Song KS, Lee IS. 1999. Antimicrobial and antitumor activity of triterpenoids fraction from Poria cocos Wolf. J Korean Soc Food Sci Nutr 28: 1029-1033.   과학기술학회마을
14 Kim DG, Son DH, Choi UK, Cho YS, Kim SM. 2002. The antioxidant ability and nitrite scavenging ability of Poria cocos. J Korean Soc Food Sci Nutr 31: 1097-1101.   과학기술학회마을   DOI
15 Kwak CS, Kim MY, Lee MS. 2005. Antioxidative effect of plant food mixtures in rat fed on high fat-high cholesterol diet. Korean J Nutr 38: 352-363.   과학기술학회마을
16 Park BH, Park JW. 2001. The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NF kappa B activation. Exp Mol Med 33: 64-68.   DOI   ScienceOn
17 Rho HW, Lee JN, Koo BS, Zhao ZL, Park JW, Kim HR. 2002. Therapeutic effect of Amomum xanthoides extract on experimental diabetes induced by alloxan. Korean Diabetes J 26: 126-133.
18 Cho HS, Lee SJ, Shin JH, Kang MJ, Cho HS, Lee HJ, Sung NJ. 2007. Antioxidative activity and nitrite scavenging effect of the composites containing medicinal plant extract. J Life Sci 17: 1135-1140.   DOI
19 Kirkinezos IG, Moraes CT. 2001. Reactive oxygen species and mitochondrial disease. Semin Cell Dev Biol 12: 449-457.   DOI   ScienceOn
20 Cho HS, Shin JH, Lee SJ, Kang MJ, Cho HS, Sung NJ. 2007. Lipid compositions changes of seasoned pork prepared with medicinal plant extracts during storage. J Life Sci 17: 1675-1681.   과학기술학회마을   DOI
21 Oh SI, Lee MS. 2003. Screening for antioxidative and antimutagenic capacities in seven common vegetables taken by Korean. J Korean Soc Food Sci Nutr 32: 1344-1350.   DOI
22 Choe SY, Yang KH. 1982. Toxicological studies of antioxidants butylated hydroxytoluene (BHT) and butylated hydroxyanisol (BHA). Korean J Food Sci Technol 14: 283- 288.
23 Larson RA. 1988. The antioxidant of higher plants. Phytochemistry 27: 969-978.   DOI   ScienceOn
24 Ju JC, Shin JH, Lee SJ, Cho HS, Sung NJ. 2006. Antioxidative activity of hot water extracts from medicinal plants. J Korean Soc Food Sci Nutr 35: 7-14.   과학기술학회마을   DOI
25 Kim EY, Baik IH, Kim JH, Kim SR, Rhyu MR. 2004. Screening of the antioxidant activity of some medicinal plants. Korean J Food Sci Technol 36: 333-338.   과학기술학회마을
26 Nam SH, Kang MY. 2000. Screening of antioxidative activity of hot-water extracts from medicinal plants. J Korean Soc Agric Chem Biotechnol 43: 141-147.   과학기술학회마을
27 Kim JO, Kim JB, Kim HY. 2009. Anti-oxidative activity of the herb mixture prescribed to induce blood glucose level and effect on the differentiation of 3T3-L1 fibroblast. Korean J Food Preserv 16: 115-121.   과학기술학회마을
28 Lee SJ, Cha JY, Shin JH, Chung MJ, Sung NJ. 2008. Antioxidant effect of Wa-song (Orostachys japonicus A. Berger) extracts on edible oil and fat. J Life Sci 18: 1106- 1114.   과학기술학회마을   DOI
29 Lee JH, Lee SJ, Park S, Kim HK, Jeong WY, Choi JY, Sung NJ, Lee WS, Lim CS, Kim GS, Shin SC. 2011. Characterisation of flavonoids in Orostachys japonicus A. Berger using HPLC-MS/MS: contribution to the overall antioxidant effect. Food Chem 124: 1627-1633.   DOI   ScienceOn
30 Lee KA, Chung HY. 2004. Biological activities a Korean traditional prescription, Nogyongdaebotang. J Korean Soc Food Sci Nutr 33: 28-33.   과학기술학회마을   DOI
31 Jang KH, Park HW, Lee DJ. 2011. Evaluation of antioxidant, anticancer and tyrosinase inhibition activities in Labiatae herb plants. Korean J Intl Agri 23: 81-88.
32 Cha BC. 2011. Tyrosinase, hyaluronidase inhibitory effect and antioxidant activity of medicinal plants. Kor J Pharmacogn 42: 89-97.   과학기술학회마을
33 Woo YM, Kim AJ, Kim J, Lee CH. 2011. Tyrosinase inhibitory compounds isolated from Persicaria tinctoria flower. J Appl Biol Chem 54: 47-50.   DOI
34 Choi JW, Kim KH, Lee IK, Choi SU, Lee KR. 2009. Phytochemical constituents of Amomum xanthioides. Nat Prod Sci 15: 44-49.   과학기술학회마을
35 Kwon MS, Chung SK, Choi JU, Song KS, Lee IS. 1999. Antimicrobial and antitumor activity of triterpenoids fraction from Poria cocos Wolf. J Korean Soc Food Sci Nutr 28: 1029-1033.   과학기술학회마을
36 Ryu BH, Park CO. 1997. Antioxidant effect of green tea extracts on enzymatic activities of hairless mice skin induced by ultraviolet B light. Korean J Food Sci Technol 29: 355-361.   과학기술학회마을
37 Heo HJ, Kim YJ, Chung D, Kim DO. 2007. Antioxidant capacities of individual and combined phenolics in a model system. Food Chem 104: 87-92.   DOI   ScienceOn
38 Jung SJ, Lee JH, Song HN, Seong NS, Lee SE, Baek NI. 2004. Screening for antioxidant activity of plant medicinal extracts. J Korean Soc Appl Biol Chem 47: 135-140.   과학기술학회마을
39 Lee SJ, Song EJ, Lee SY, Kim KBWR, Kim SJ, Yoon SY, Lee CJ, Ahn DH. 2009. Antioxidant activity of leaf, stem and root extracts from Orostachys japonicus and their heat and pH stabilities. J Korean Soc Food Sci Nutr 38: 1571- 1579.   과학기술학회마을   DOI
40 Wasser SP, Ewis AL. 1999. Therapeutic effects of substances occurring in higher basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol 19: 65-96.
41 Kim JP, Chon IJ, Cho HK, Ham IH, Whang WK. 2004. The antioxidant and the antidiabetic effects of ethanol extract from biofunctional foods prescriptions. Kor J Pharmacogn 35: 98-103.
42 Yen GC, Chen HY. 1995. Antioxidant activity of various tea extracts in relation to their antimutagenicity. J Agric Food Chem 43: 27-32.   DOI   ScienceOn
43 Shin JH, Kang MJ, Lee SJ, Yang SM, Rue GH, Sung NJ. 2009. Biological activities of dried garlic, red ginseng and their mixture. J Korean Soc Food Sci Nutr 38: 1633-1639.   과학기술학회마을   DOI
44 Kim KD. 2007. Research of efficacy & stability about mixed medicinal plants extracts. J Kor Soc Cosm 13: 601-608.
45 Devi SL, Kannappan S, Anuradha CV. 2007. Evaluation of in vitro antioxidant activity of Indian bay leaf, Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm using rat brain synaptosomes as model system. Indian J Exp Biol 45: 778-784.