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http://dx.doi.org/10.3746/jkfn.2012.41.1.007

Hepatoprotective Effect of Curdrania tricuspidata Extracts against Oxidative Damage  

Kim, Ok-Kyung (Dept. of Medical Nutrition, Kyung Hee University)
Ho, Jin-Nyoung (Dept. of Medical Nutrition, Kyung Hee University)
Nam, Da-Eun (Dept. of Medical Nutrition, Kyung Hee University)
Jun, Woo-Jin (Dept. of Food and Nutrition, Chonnam National University)
Hwang, Kwon-Tack (Dept. of Food and Nutrition, Nambu University)
Kang, Jung-Eun (Barammaji)
Chae, Ok-Soon (Barammaji)
Lee, Jeong-Min (Dept. of Medical Nutrition, Kyung Hee University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.1, 2012 , pp. 7-13 More about this Journal
Abstract
We investigated the antioxidant and hepatoprotective effects of extracts from the leaves, stems, and fruit of Cudrania tricuspidata (CT) against $H_2O_2$ or ethanol-induced oxidative damage. The total polyphenol and flavonoid content was the highest in the 80% ethanol extracts from the leaves of the plant (CTL80). Also, the radical scavenging activity of DPPH and ABTS in the CTL80 was significantly higher than that of the non-treated control. To determine the hepatoprotective effects of CT in $H_2O_2$ and ethanol-induced oxidative damage, cell viability was measured using an XTT assay. Pre-treatment of CTL80 significantly increased cell viability compared with the non-treated control cells by 71.21% and 80.40%, respectively. The data suggests that CTL80 exhibits hepatoprotective antioxidant effects. Therefore, CTL80 may be considered a potential agent to control $H_2O_2$ or ethanol-induced liver damage.
Keywords
Cudrania tricuspidata; antioxidative activity; hepatoprotective effect; oxidative stress;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 2
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