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http://dx.doi.org/10.3746/jkfn.2012.41.12.1727

Biological Effect of Vaccinium uliginosum L. on STZ-induced Diabetes and Lipid Metabolism in Rats  

Han, Eun-Kyung (Dept. of Food and Nutrition and Korea Nutrition Institute, Hallym University)
Kwon, Hyuck-Se (Dept. of Food and Nutrition and Korea Nutrition Institute, Hallym University)
Shin, Se-Gye (Dept. of Food and Nutrition and Korea Nutrition Institute, Hallym University)
Choi, Yoon-Hee (Dept. of Food and Nutrition and Korea Nutrition Institute, Hallym University)
Kang, Il-Jun (Dept. of Food and Nutrition and Korea Nutrition Institute, Hallym University)
Chung, Cha-Kwon (Dept. of Food and Nutrition and Korea Nutrition Institute, Hallym University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.12, 2012 , pp. 1727-1733 More about this Journal
Abstract
This study was conducted to investigate the effects of Vaccinium uliginosum L. (bilberry) on chemically induced diabetes and hypercholesterolemia. Sprague Dawley (SD) rats were divided into six groups, control (CON), bilberry added group (CBB), streptozotocin (STZ)-induced diabetic group (STZ), STZ and bilberry added group (SBB), high fat fed group (HFF) and high fat and bilberry added group (HFB). Diabetes was chemically induced by intravenous injection of 45 mg/kg body weight STZ in citrate buffer (pH 4.5). Serum triglycerides decreased significantly (p<0.05) in the STZ group that was fed bilberry. Additionally, the athrogenic index (AI) decreased significantly (p<0.05) when compared to the STZ group, while the liver triglycerides tended to decrease in the STZ group. HDL-cholesterol also increased significantly in response to bilberry. When compared to the STZ group, steady attenuation of the blood glucose level was observed upon fasting, 15 min, 30 min, 60 min and 120 min after oral glucose administration. The blood glucose level in the bilberry fed group decreased by 24% when compared to STZ group, while the superoxide dismutase (SOD) became significantly higher (p<0.05) in the STZ group when compared to the CON group. Overall, the results of this study suggest that bilberry stimulates lipid metabolism in both the serum and liver and has a positive effect on glucose metabolism in chemically induced diabetic rats.
Keywords
Vaccinium uliginosum L; streptozotocin; diabetes; blood glucose; lipid metabolism;
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