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http://dx.doi.org/10.3746/jkfn.2010.39.9.1243

Antioxidant and Alpha-Glucosidase Inhibitory Activity of Strychnos nux-vomica Extracts  

Lee, Jeung-Min (Dept. of Food Science and Biotechnology, Kyungnam University)
Park, Jae-Hee (Dept. of Food and Nutrition, Kyungnam University)
Park, Hae-Ryong (Dept. of Food Science and Biotechnology, Kyungnam University)
Park, Eun-Ju (Dept. of Food and Nutrition, Kyungnam University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.39, no.9, 2010 , pp. 1243-1248 More about this Journal
Abstract
The physiological activities of Strychnos nux-vomica extracts were investigated through the total phenolic contents (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (RSA), comet assay, and $\alpha$-glucosidase inhibitory activity. S. nux-vomica extracts were prepared with methanol, ethanol, and acetone. The methanol extract showed the highest phenolic content (71 mg/100 g gallic acid equivalents). Pretreatment with S. nux-vomica extracts resulted in significant reductions in oxidative DNA damage at all of the concentrations tested ($1{\sim}50\;{\mu}g/mL$). The $\alpha$-glucosidase inhibitory activity of a methanol extract was 12.8% at the concentration of 1 mg/mL. Therefore, these results indicate that S. nux-vomica might be a noble potential candidate exhibiting antioxidant and $\alpha$-glucosidase inhibitory activity.
Keywords
Strychnos nux-vomica; antioxidant; anti-$\alpha$-glucosidase; comet assay;
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