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http://dx.doi.org/10.3746/jkfn.2010.39.2.210

Cholesterol-lowering and Anti-obesity Effects of Polymnia Sonchifolia Poepp. & Endl. Powder in Rats Fed a High Fat-High Cholesterol Diet  

Kim, Ah-Ra (Dept. of Food and Nutrition, Chosun University)
Lee, Jae-Joon (Dept. of Food and Nutrition, Chosun University)
Lee, Yu-Mi (Dept. of Food and Nutrition, Chosun University)
Jung, Hae-Ok (Dept. of Culinary Art, Chodang University)
Lee, Myung-Yul (Dept. of Food and Nutrition, Chosun University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.39, no.2, 2010 , pp. 210-218 More about this Journal
Abstract
This study was carried out to investigate the effect of Yacon (Polymnia sonchifolia Poepp. & Endl.) powder on cholesterol-lowering and anti-obesity effects in rats fed a high fat-high cholesterol diet for 4 weeks to induce hyperlipidemic and obese rat model. Weight-matched male Sprague-Dawley rats were assigned to four groups according to dietary fat, cholesterol levels and Yacon powder levels. Experimental groups were normal diet group (N), high fat-high cholesterol diet group (HFC), high fat-high cholesterol diet with 5% Yacon powder group (HFC-PSL) and high fat-high cholesterol diet with 10% Yacon powder group (HFC-PSH). The body weight gain and FER were increased by a high fat-high cholesterol diet, but gradually decreased in the Yacon powder fed groups compared with the HFC group. Food intake was lower in HFC groups compared with N group. The liver and adipose tissue weights of HFC group were heavier than those of N group, whereas those of groups administered Yacon powder were gradually decreased. The serum ALT, AST, ALP and LDH activities elevated by a high fat-high cholesterol diet were significantly decreased by Yacon powder administration. Levels of serum total cholesterol, LDL-cholesterol, atherogenic index and cardiac risk factor showed a decreasing tendency in the Yacon powder fed groups compared with HFC group. The serum HDL-cholesterol level decreased in the HFC group and markedly increased in the Yacon powder fed groups. Levels of total cholesterol and triglyceride in liver and adipose tissues were lower in Yacon powder administered groups than those in HFC group. These results suggest that Yacon powder may improve lipid metabolism of serum, liver, and adipose tissue and potentially reduce lipid storage.
Keywords
Yacon (Polymnia sonchifolia); high fat-high cholesterol diet; cholesterol; anti-obesity;
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Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By SCOPUS : 1
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1 Oh SJ, Kim WK, Kim YH, Kim HY, Choi EH, Kim SH. 1999. Effect of fructooligosaccharide on lipid metabolism in hypercholesterolemic rat. Korean J Food & Nutr 32: 129-136.   과학기술학회마을
2 Ide T, Moriuchi H, Nihimoto K. 1991. Hypolipidemic effects of guar gum and its enzyme hydrolysate in rats fed highly saturate fat diets. Ann Nutr Metab 35: 34-44.   DOI
3 Lee FZ, Lee JC, Yang HC, Jung DS, Eun JB. 2002. Chemical composition of dried leaves and stems and cured tubers of Yacon (Polymnia sonchifolia). Korean J Food Preserv 9: 61-66.   과학기술학회마을
4 Kim HS, Kim SH, Kim GJ, Choi WJ, Chung SY. 1993. Effects of the feeding mixed oils with various level of n-3 and n-6 polyunsaturated fatty acid on the lipid components of liver, brain, testis and kidney in dietary hyperlipidemic rats. J Korean Soc Food Nutr 22: 685-691.   과학기술학회마을
5 Huh KB, Lee JH, Park IK, Ahn KJ, Jung YS, Kim MJ, Lee HC, Lee YC. 1993. Influence of total abdominal fat accumulation on serum lipid and lipoproteins in Korean middle-aged men. Korean J Nutr 26: 299-305.   과학기술학회마을
6 Kim SH, Hong MY. 1993. The change of erythrocyte feature and Ca concentration in rat fed the diet containing different common oils in Korea: sesame oil, perilla oil, rice bran oil of mixed oil. Korean J Nutr 26: 524-530.
7 Anderson JW, Smith BM, Gustafson NJ. 1994. Health benefits and practical aspects of high-fiber diets. Am J Clin Nutr 59: 1242S-1247S.   DOI
8 Folch J, Lees M, Sloane-Stanley G. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
9 Zlatkis A, Zak B. 1969. Study of a new cholesterol reagent. Anal Biochem 29: 143-148.   DOI
10 Delzenne N, Kok N. 2004. Effect of non-digestible fermentable carbohydrates on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 78: 215-222.   DOI
11 Sung HY, Jeoung HJ, Choi YS, Cho SH, Yun JW. 2004. Effects of chicory inulin and oligosaccharides on lipid metabolism in rats fed a high-cholesterol diet. J Korean Soc Food Sci Nutr 33: 305-310.   과학기술학회마을   DOI
12 Kim MJ, Jang JY, Lee MK, Park JY, Park EM. 1999. Effect of fiber on lipid concentration in hypercholesterolemic rats. Korean J Food & Nutr 12: 20-25.   과학기술학회마을
13 Chang YK, Youn HJ. 1984. The effect of dietary fat levels and sources of dietary fiber on serum and liver lipids of rats. Korean J Nutr 17: 253-261.   과학기술학회마을
14 Sollof LA, Futenberg HL, Lacko AG. 1973. Serum cholesterol esterfication in patients with coronary artery disease. Am Heart J 85: 153-161.   DOI
15 Turley E, Armstrong NC, Wallace JMW, Gilore WS, Mckelvey-Martin JV, Allen TM, Strain JJ. 1999. Effect of cholesterol feeding on DNA damage in male and female syrian hamsters. Ann Nutr Metab 43: 47-51.   DOI
16 Park OJ. 1994. Plasma lipids and fecal excretion of lipids in rats fed a high fat diet, a high cholesterol diet or a low fat/high sucrose diet. Korean J Nutr 27: 785-794.   과학기술학회마을
17 Alvarez FPP, Jurado TB, Calixto CM, Incio VN, Silva AJ. 2008. Prebiotic inulin/oligofructose in Yacon root (Smallanthus sonchifolius), phytochemistry and standardization as basis for clinical and pre-clinical research. Rev Gastroenterol Peru 28: 22-27.
18 Asami T, Kubota M, Minamisawa K, Tsukihashi T. 1989. Chemical composition of yacon, a new root crop from Andean highland. Jap J Soil Sci Plant Nutr 60: 122-126.
19 Biggs HG, Erikson TM, Moorehead WR. 1975. A manual colorimetric assay of triglyceride in serum. Clin Chem 21: 437-441.
20 Kwon EK, Choi EM, Koo SJ. 2001. Effects of mucilage from Yam (Dioscorea batatas DECENE) on blood glucose and lipid composition in alloxan-induced diabetic mice. Korean J Food Sci Technol 33: 795-801.   과학기술학회마을
21 Genta SB, Cabrera WM, Grau A, Sanchez SS. 2005. Subchronic 4-month oral toxicity study of dried Smallanthus sonchifolius (yacon) roots as a diet supplement in rats. Food Chem Toxicol 43: 1657-1665.   DOI
22 Fiordaliso M, Kok N, Desager JP, Goethals F, Deboyser D, Roberfroid M, Delzenne N. 1995. Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30: 163-167.   DOI
23 Shin HK. 1998. Development of new functional materials from inulin of chicory and jerualem artichoke. Ministry of Science and Technology. p 41-57.
24 Prosky L. 1999. Inulin and oligofructose are part of the dietary fiber complex. J AOAC Int 82: 223-229.
25 Wooller LA, Spady DK, Dietschy JM. 1992. Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate. J Lipid Res 33: 77-88.
26 Agheli N, Kabir M, Berni-Canani S, Petitiean E, Boussairi A, Luo J, Bornet F, Slama G, Salwa W, Rizkalla. 1998. Lipids and fatty acid synthase activity are regulated by short chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats. J Nutr 128: 1283-1288.   DOI
27 Balcazar-Munoz BR, Martinez-Abundis E, Gonzalez-Ortiz M. 2003. Effect of oral inulin administration on lipid profile and insulin sensitivity in subjects with obesity and dyslipidemia. Rev Med Chil 131: 597-604.
28 Jackson KG, Taylor GR, Clohessy AM, Williams CM. 1999. The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. Br J Nutr 82: 23-30.   DOI
29 Davison MH, Maki KC, Synecki C, Tomi SA, Drennan KB. 1998. Effects of dietary inulin on serum lipids in men and woment with hypercholesterolemia. Nutr Res 18: 503-517.   DOI
30 Kim MH, Shin HK. 1998. The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats. J Nutr 128: 1731-1736.   DOI
31 Kang HJ, Song YS. 1997. Dietary fiber and cholesterol Metabolism. J Korean Soc Food Sci Nutr 26: 358-369.   과학기술학회마을
32 Kwon JY, Cheigh HS, Song YO. 2004. Weight reduction and lipid lowering effects of kimchi lactic acid powder in rats fed high rat diets. Korean J Food Sci Technol 36: 1014-1019.   과학기술학회마을
33 Schaafsma G, Meuling WJ, van Dokkum W, Bouley C. 1998. Effects of a milk product, fermented by Lactobacillus acidophilus and with fructooligosaccharides added, on blood lipids in male volunteers. Eur J Clin Nutr 52: 436-476.   DOI
34 Park SO. 1995. Effects of aloe vera powder on lipid metabolism in rats fed cholesterol added diet. PhD Dissertation Ewha Women's University, Seoul, Korea.
35 Trautwein EA, Rieckhoff D, Erbersdobler HF. 1998. Dietary inulin lowers plasma cholesterol and triacylglycerol and alters biliarybile acid profile in hamsters. J Nutr 128: 1937-1943.   DOI
36 Kim YS. 2005. Antimicrobial activity of Yacon K-23 and manufacture of functional Yacon jam. Korean J Food Sci Technol 37: 1035-1038.   과학기술학회마을
37 Shin DY, Choi GL, Cho YS, Kwon BS, Kim HJ, Hyun KH, Lim JT. 2007. Development of functional tea made by yacon leaf (Polymina sonchifolia PEOPP.) Korean J Plant Res 5:144.
38 Min KJ, Cheon JU, Cha CG. 2008. Antioxidative and anticancer activities of extracting of Yacon. J Fd Hyg Safety 23: 163-168.
39 Reeves PG, Nielson FH, Fahey Jr GC. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951.   DOI
40 Friedwald W, Levy R, Fredrickson D. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
41 Rosenfeld L. 1989. Lipoprotein analysis. Arch Pathol Lab Med 113: 1101-1110.
42 Kang JA, Kang JS. 1997. Effect of garlic and onion on plasma and liver cholesterol and triglyceride and platelet aggregation in rats fed basal or cholesterol supplemented diets. Korean J Nutr 30: 132-138.   과학기술학회마을
43 Ohyama T, Ito I, Yasuyoshi S, Ikarashi T, Minamisawa K, Kubota M, Tsukihashi T, Asami T. 1990. Composition of storage carbohydrate in tubers of yacon (Polymnia sonchifolia). Soil Sci Plant Nutr 36: 167-171.   DOI
44 Goto K. 1995. Isolation and structural analysis of oligosaccharides from Yacon (Polymnia sonchifolia). Biosci Biotechnol Biochem 59: 2346-2347.   DOI
45 Cazetta ML, Martins PMM, Monti R, Contiero J. 2005. Yacon (Polymnia sanchifolia) extract as a substrate to produce inulinase by Kluyveromyces marxianus var. bulgaricus. J Food Eng 66: 301-305.   DOI