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http://dx.doi.org/10.3746/jkfn.2010.39.11.1595

Effect of Dietary Grape Pomace on Lipid Metabolism and Hepatic Morphology in Rats Fed a High Fat Diet  

Zhang, Xian-Hua (Dept. of Food and Nutrition, Yeungnam University)
Choi, Soo-Kyong (Dept. of Food and Nutrition, Yeungnam University)
Seo, Jung-Sook (Dept. of Food and Nutrition, Yeungnam University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.39, no.11, 2010 , pp. 1595-1603 More about this Journal
Abstract
The present study was conducted to investigate the effect of dietary grape pomace on lipid metabolism and hepatic morphology of rats fed a high fat diet. The high fat diet contained additional 15% lard to AIN 93-based diet. Male Sprague-Dawley rats were fed experimental diets containing 5% grape pomace for 4 weeks. Serum activities of glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) were not changed by high fat and grape pomace feeding. Serum concentration of triglyceride in rats fed a high fat diet was decreased significantly by dietary grape pomace. Hepatic concentrations of total lipid, total cholesterol and triglyceride were reduced in grape pomace groups with a high fat diet. Fecal concentrations of total cholesterol and triglyceride were increased in grape pomace groups with a high fat diet. The fecal content of coprostanol was not different among the groups. Dietary grape pomace increased the fecal excretion of cholesterol and coprostanone in rats fed a high fat diet. The fecal excretion of bile acid was not affected by feeding grape pomace in rats fed a high fat diet. Light micrographs of liver tissue revealed lipid droplets were increased by a high fat diet, but dietary supplementation of grape pomace tended to alleviate such changes.
Keywords
grape pomace; high fat diet; lipid metabolism; hepatic morphology;
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Times Cited By KSCI : 6  (Citation Analysis)
Times Cited By SCOPUS : 2
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