Browse > Article
http://dx.doi.org/10.3746/jkfn.2010.39.10.1439

Effects of Phyto-Extract Mixture on Adiposity and Serum Lipid Levels in Obese Mice Induced by High Fat Diet  

Jang, Young-Sun (Technology Research Center, Ben's Lab Co., Ltd.)
Jeong, Jong-Moon (Dept. of Life Science, The University of Suwon)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.39, no.10, 2010 , pp. 1439-1445 More about this Journal
Abstract
In this study, we investigated the inhibition of phyto-extract mixture (PEM) in several digestive enzymes ($\alpha$-amylase, $\alpha$-glucosidase and lipase) for anti-obesity. The current study also examined the effects of PEM on adiposity and serum lipid levels in obese mice fed with high fat diet. ICR male mice weighing $33{\pm}1.1\;g$ were randomly divided into three groups, one normal diet group (control, ND group) and two high fat diet groups with or without PEM supplement (HFD group and PEM group). The mice were fed the PEM experimental for 6 weeks and then they were sacrificed. The results showed that the final weight, weight gain, food efficiency ratio and body fat were decreased by the addition of PEM compared to those of HFD group. White adipose tissue weights of epididymal, mesenteric and retroperitoneal areas in the PEM group were reduced to 31.2%, 8.8%, and 37.8%, respectively, compared to the HFD group. The levels of serum triglyceride, total cholesterol, LDL-cholesterol in the PEM group were significantly lower than those of HFD group. The body weight gain and food efficiency ratio of PEM group were significantly lower compared with those of HFD group. From the above results, the PEM may be effective material for anti-obesity through reducing serum triglyceride and body fats as well as decreasing body weight.
Keywords
anti-obesity; LDL-cholesterol; triglyceride; body fat; high-fat diet;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By SCOPUS : 3
연도 인용수 순위
1 Kim YJ, Kim BH, Lee SY, Kim MS, Park CS, Rhee MS, Lee KH, Kim DS. 2006. Screening of medicinal plants for development of functional food ingredients with antiobesity. J Korean Soc Appl Biol Chem 49: 221-226.
2 Park SH, Ko SK, Chung SH. 2005. Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat in ICR mice. J Ethnopharmacol 102: 326-335.   DOI
3 Wat E, Tandy S, Kapera E, Kamili A, Chung RWS, Brown A, Brown A, Rowney M, Cohn JS. 2009. Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high fat diet. Atherosclerosis 205: 144-150.   DOI
4 Gotto AM Jr, Farmer JA. 2006. Drug insight: the role of statins in combination with ezetimibe to lower LDL cholesterol. Nat Clin Pract Cardiovasc Med 3: 664-672.   DOI
5 Lee KS, Kim JB. 2009. Effects of the Sarcodon aspratus on the high level of blood lipid and obesity induced by high fat-diet in rat. Korean J Life Science 19: 1265-1270.   DOI
6 Davignon J, Cohn JS. 1996. Triglyceride: a risk factor for coronary heart disease. Atherosclerosis 124: S57-64.   DOI
7 Miller WC, Lindeman AK, Wallace J, Niedeerpruem M, 1990. Diet composition, energy intake, and exercise in relation to body fat in men and women. Am J Clin Nutr 52: 426-430.   DOI
8 Bjorntorp P. 1988. The associations between obesity, adipose tissue distribution and disease. Acta Med Scand 723: 121-134.
9 Bjorntorp P. 1990. "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Atherosclerosis 10: 493-496.
10 Despres JP. 1993. Abdominal obesity as important component of insulin-resistant syndrome. Nutrition 19: 452-469.
11 Burns AA, Livingstone MB, Welch RW, Dunne A, Rowland IR. 2002. Dose-response effects of a novel fat emulsion (Olibra) on energy and macronutrient intake up to 36 h post-consumption. Eur J Clin Nutr 56: 368-377.   DOI
12 Delzenne NM, Cani PD, Daubioul C, Neyrinck AM. 2005. Impact of insulin and oligofructose on gastrointestinal peptides. Br J Nutr 1: 157-161.
13 Zacour AC, Silva ME, Cecon PR, Bambirra EA, Vieira EC. 1992. Effect of dietary chitin on cholesterol absorption and metabolism in rats. J Nutr Sci Vitaminol 38: 609-613.   DOI   ScienceOn
14 Griffiths DW. 1986. The inhibition of digestive enzymes by polyphenolic compounds. Adv Exp Med Biol 1999: 509-516.
15 Lee SK, So SH, Hwang EI, Koo BS. 2008. Effect of ginseng and herbal plant mixtures on anti-obesity in obese SD rat induced by high fat diet. J Korean Soc Food Sci Nutr 37: 437-444.   DOI
16 Williams JA, Goldfine ID. 1985. The insulin-pancreatic acinarxis. Diabetes 34: 980-985.   DOI
17 Park JH, Lee YC. 1985. Studies on the immobilization of lipase by adsorption method. Korean J Food Sci Technol 17: 75-80.
18 Kim CH, Cheigh HS, Byun SM. 1984. A simple and modified photometric method for measuring lipase activity. Korean J Food Sci Technol 16: 251-253.
19 Bernfeld P. 1955. Amylase ${\alpha}$ and ${\beta}$. In Method on Enzymology. Colowick SP, Kaplan NO, eds. Academic Press, New York, USA. Vol 1, p 52.
20 Kim SG, An GH, Yoon SW, Lee YC, Ha SD. 2003. A study on dietary supplement to reduce obesity by the mechanism of decreasing lipid and carbohydrate absorption. Korean J Food Sci Technol 35: 519-526.
21 Saisuburamaniyan N, Krithika L, Dileena KP, Sivasubramanian S, Puvanakrishnan R. 2004. Lipase assay in soils by copper soap colorimetry. Anal Biochem 330: 70-73.   DOI
22 Ministry of Health & Welfare. 2006. The Third Korea National Health and Nutrition Examination Survey (KNHANES III) 2005 summary.
23 Kim YH, Yoo JY, Lee EU, Kim KB, Jo DH, Hwang JY. 2004. Effects of a dietary supplement consisting of Phaseolus vulgaris and Garcinia cambogia (HCA) on the lipid level and body weight. J Korean Soc Food Sci Nutr 33: 518-522.   DOI
24 Kopelman PG. 2005. Obesity as medical problem. Nature 404: 635-643.   DOI
25 King DJ, Devaney N. 1988. Clinical pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant, in healthy volunteers. Br J Pharmacol 26: 607-611.   DOI
26 Mason EE. 1992. Methods for voluntary weight loss and control. Obes Surg 2: 275-276.   DOI
27 George AB, Louis AT. 2000. Medicinal strategies in the treatment of obesity. Nature 404: 672-677.   DOI