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http://dx.doi.org/10.3746/jkfn.2009.38.6.674

Effects of Compositae Plants on Plasma Glucose and Lipid Level in Streptozotocin Induced Diabetic Rats  

Han, Hye-Kyoung (Plant Resources Research Institute, Duksung Women's University)
Yoon, Su-Jin (Dept. of Food and Nutrition, Duksung Women's University)
Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.6, 2009 , pp. 674-682 More about this Journal
Abstract
This study was designed to examine the effects of Compositae plants on plasma glucose and lipid levels in streptozotocin (STZ) induced diabetic rats. Sprague-Dawley rats were randomly assigned to 5 groups: normal, STZ-control and three experimental groups [Artemisia iwayomogi (A. iwayomogi), Atractylodes lancea (A. lancea), and Taraxacum mongolicum (T. mongolicum)]. Normal and STZ-control group were fed an AIN-93 diet and three experimental groups were each fed a modified diet containing 10% compositae powder for 4 weeks. The plasma glucose levels at 4 weeks of A. iwayomogi, A. lancea, and T. mongolicum groups were significantly lower than STZ-control group. The A. iwayomogi and A. lancea groups had significantly suppressed hypertrophy of liver and kidney. The hematocrit levels of A. lancea and T. mongolicum group were significantly lower than STZ-control groups. The total cholesterol and triglyceride levels and atherogenic index (AI) of A. lancea group were significantly lower than STZ-control group. Intake of Compositae plants may be effective in antihyperglycemia by lowering blood glucose levels. The A. iwayomogi, A. lancea, and T. mongolicum can be beneficial for the diabetic complications and damage from the lipid peroxidation.
Keywords
Compositae plants; diabetic rats; hypoglycemic effect;
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1 Lee SJ, Park JY, Nam CM, Jee SH. 2008. The prevalence estimation of metabolic syndrome and it's related factors based on data from general health medical examination: a multi-center study. J Korean Soc Health Information Health Statistics 33: 119-133
2 Zhang H, Han T, Sun LN, Huang BK, Chen YF, Zheng HC, Qin LP. 2008. Regulative effects of essential oil from Atractlodes lancea on delayed gastric emptying in stressinduced rats. Phytomedicine 15: 602-611   DOI   ScienceOn
3 Reeves PG. 1997. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 127: 838S-841S
4 Bauer JD. 1982. Clinical laboratory methods. 9th ed. Mosby Co., St. Louis, USA. p 188-189
5 Hassid WZ, Abraham X. 1957. Chemical procedures for analysis of polysaccharides. In Methods in Enzymology. Academic press, New York, USA. Vol 3, p 34-50
6 Reitman S, Frankel S. 1957. A colorimetric method the determination of serum glutamic oxalacetic and glutamine pyruvic transaminases. Am J Clin Pathol 28: 58-63
7 Kim SH, Cho CH, Kim SY, Eun JS, Shin TY. 2005. Anti-allergic effect of Artemisia iwayomogi on mast cell-mediated allergy model. Exp Biol Med 230: 82-88   DOI
8 Yu KW, Shin KW. 2001. Bone marrow cell proliferation activity through intestinal immune system by the components of Atractylodes lancea DC. Korean J Food Sci Technol 33: 135-141   과학기술학회마을
9 Wei S, Zhou Q, Wang X. 2005. Identification of weed plants excluding the uptake of heavy metals. Environ Int 31: 829-834   DOI   ScienceOn
10 Richmond W. 1973. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to enzymatic assay of total cholesterol in serum. J Clin Chem 19: 1350-1356
11 Finely PR, Schifman RB, Williams RJ, Luchti DA. 1978. Cholesterol in high-density lipoprotein: Use of $Mg^{2+}$/dextran sulfate in its measurement. J Clin Chem 24: 931-933
12 Lee JS, Son HS, Maeng YS, Chang YK, Ju JS. 1994. Effects of buckwheat on organ weight, glucose and lipid metabolism in streptozotocin-induced diabetic rats. Korean J Nutr 27: 819-827   과학기술학회마을
13 Rhee SJ, Shin JY, Cha BG. 1998. Effect of green tea catechin on the microsomal mixed function oxidase system of kidney and brain in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 27: 319-325   과학기술학회마을
14 Koh JB, Choi MA, Kim JY, Rho MH, Kim DJ. 1999. Effects of tea fungus/kombucha beverage on serum protein levels and enzyme activity in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 28: 1137-1143   과학기술학회마을
15 Davis RH, Rosenthal KY, Cesasrio LR, Rouw GA. 1989. Processed Aloe vera administered topically inhibits inflammation. J Am Podiatr Med Assoc 79: 395-397   DOI
16 Kimura Y, Okuda H, Okuda T, Hatano T, Agata I, Arichi S. 1985. Studies on the activities of tannins and related compounds from medicinal plants and drugs. VII. Effects of extracts of leaves of Artemisia species and caffeic acid chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil. Chem Pharm Bull 33: 2028-2034   DOI   ScienceOn
17 Rho HM, Choi M, Koh JB. 1998. Effects of serum raw soy flour (yellow and black) on protein concentrations and enzyme activity. J Korean Soc Food Sci Nutr 27: 724-730   과학기술학회마을
18 Kim SH, Kang JS, Lee SJ, Chung YJ. 2008. Antidiabetic effect of Korean red ginseng by puffing process in streptozotocin- induced diabetic rats. J Korean Soc Food Sci Nutr 37: 701-707   과학기술학회마을   DOI   ScienceOn
19 Seo KH, Choi JS, Na JO, Uh ST, Kim YH, Park CS. 2006. Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 after administration of endotoxin in diabetic rats. Tuberc Respir Dis 61: 256-264   DOI   ScienceOn
20 Goldstein LJ, Brown SM. 1977. The low-density lipoprotein pathway and its relation to atherosclerosis. Annual Rev Biochem 46: 897-930   DOI   ScienceOn
21 Barbera A, Rodriguez-Gil JE, Guinovart JJ. 1994. Insulinlike actions of tungstate in diabetic rats. Normalization of hepatic glucose metabolism. J Biol Chem 269: 20047-20053
22 O'Meara NM, Devery RA, Owens D, Collins PB, Johnson AH, Tomkin GH. 1990. Cholesterol metabolism in alloxan induced diabetic rabbits. Diabetes 39: 629-633   DOI   ScienceOn
23 Durrington PN, Stephens WP. 1980. The effects of treatment with insulin on serum high-density-lipoprotein cholesterol in rats with streptozotocin-induced diabetes. Clin Sci 59: 71-74   DOI
24 Betteridge J. 2001. Dyslipidaemia and diabetes. Prac Diabetes Intern 18: 201-207   DOI   ScienceOn
25 Nikkila EA, Kekki M. 1973. Plasma triglyceride transport kinetics in diabetes mellitus. Metabolism 22: 1-22   DOI   ScienceOn
26 Baynes W. 2003. Chemical modification of protein by lipids in diabetes. Clin Chem Lab Med 41: 1159-1165   DOI   ScienceOn
27 Reaven GM. 1988. Role of insulin resistance in human disease. Diabetes 37: 1597-1607   DOI   ScienceOn
28 O'Brien RM, Granner DK. 1996. Regulation of gene expression by insulin. Physiol Rev 76: 1109-1161
29 Somogy A, Pusztai P, Prechl J, Feher J. 1994. Hypothetical connection between diabetes mellitus and free radical reactions in atherosclerosis. Ory Hetil 135: 1815-1818
30 Marles RJ, Farnsworth NR. 1995. Antidiabetic plants and their active constituents. Phytomedicine 2: 137-189   DOI   ScienceOn
31 Ham SS, Chung CK, Lee JH, Choi K, Jung SW, Kim EJ. 1998. Antimutagenicity and cytotoxicity of Artemisia iwayomogi Kitamura extracts. J Korean Soc Food Sci Nutr 27: 157-162   과학기술학회마을
32 Lee JA, Sung HN, Jeon CH, Gill BC, Oh GS, Youn HJ, Park JH. 2008. A carbohydrate fraction, AIP1 from Artemisia iwayomogi suppresses pulmonary eosinophilia and Th2- type cytokine production in an ovalbumin-induced allergic asthma. Down-regulation of TNF-$\alpha$ expression in the lung. Int Immunopharmacol 8: 117-125   DOI   ScienceOn
33 Establishment of data base on the law materials and their components used in the functional foods. 2005. Korea Food & Drug Administration
34 Nakai Y, Kido T, Hashimoto K, Kase Y, Sakakibara I, Higuchi M, Sasaki H. 2003. Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying. J Ethnopharmacol 84: 51-55   DOI   ScienceOn
35 Williams KV, Mullen ML, Kelly DE, Wing RR. 1998. The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes. Diabetes Care 21: 2-8   DOI   ScienceOn
36 Giegel JL, Ham SB, Clema W. 1975. Serum triglyceride determined colorimetry with an enzyme that produces hydrogen peroxide. J Clin Chem 21: 1575-1581
37 Kanai I, Kanai M. 1983. Compendium of the clinical inspection. 29th ed. Komoonsa, Seoul. p 467
38 Malabu UH, Dryden S, Mccarthy HD, Kilpatrick A, Williams G. 1994. Effect of chronic vanadate administration in the STZ-induced diabetic rats: The antihyperglycemic action of vanadate is attributable entirely to its suppression of feeding. Diabetes 43: 9-15   DOI   ScienceOn
39 Chang MW, Jhonson MA. 1980. Effect of garlic on carbohydrate metabolism and lipid synthesis in rats. J Nutr 110: 931-936
40 Shanmugasundaram ER, Gopith KI, Radha SK, Rajendran VM. 1990. Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestere leaf extract. J Ethnopharmacol 30: 265-269   DOI   ScienceOn
41 Steer KA, Sochor M, McLean P. 1985. Renal hypertrophy in experimental diabetes changes in pentose phosphate pathway activity. Diabetes 34: 485-490   DOI   ScienceOn
42 Yang YR, Kim HL, Park YK. 2008. Effects of onion kimchi extract supplementation on blood glucose and serum lipid contents in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 37: 445-451   과학기술학회마을   DOI   ScienceOn
43 Park JH. 2004. Medicinal plants of Korea. Shinil Books Company, Seoul. p1316, 1338, 1426-1427
44 Hwang JS, Ji HJ, Koo KA, Lee NH, Yeo HK, Cheong SW, Park JH, Oh GS, Yoon CS, Youn HJ. 2005. AIP1, a water- soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of fas gene. Biol Pharm Bull 28: 921-924   DOI   ScienceOn
45 Song YE, Ryu JS, Chung JR, Kwak JS, Kim DH, Kim BS, Rim CW. 2001. Study on the biological activity of Artemisia iwayomogi Kitamura. Korean J Medicinal Crop Sci 9: 116-123   과학기술학회마을
46 Rabbo E, Terkildsen TC. 1968. On the enzymatic determination of blood glucose. Scandinav J Lab Invest 12: 402-407   DOI
47 Goldberg RB. 1981. Lipid disorders in diabetes. Diabetes Care 4: 561-572   DOI   ScienceOn
48 Dai S, Thompson KH, McNeill JH. 1994. One-year treatment of streptozotocin-induced diabetic rats with vanadyl sulphate. Pharmacol Toxicol 74: 101-109   DOI
49 Dai S, McNeill JH. 1994. One-year treatment of non-diabetic and streptozotocin diabetic rats with vanadyl sulphate did not alter blood pressure or heamatological indices. Pharmacol Toxicol 74: 110-115   DOI
50 Tsneki H, Ma EL, Kobayashi S, Sekizaki N, Maekawa K, Sasaoka T, Wang MW, Kimura I. 2005. Antiangiogenic activity of $\beta$-eudemol in vitro and in vivo. Eur J Pharmacol 512: 105-115   DOI   ScienceOn
51 Wei S, Zhou Q, Mathews S. 2008. A newly found cadmium accumulator－Taraxacum mongolicum. J Hazard Mater 30: 544-547   DOI   ScienceOn
52 Kahn CR. 1985. The molecular mechanism of insulin action. Ann Rev Med 36: 249-251   DOI   ScienceOn
53 Ugochukwu NH, Figgers CL. 2007. Attenuation of plasma dyslipidemia and oxidative damage by dietary caloric restriction in streptozotocin-induced diabetic rats. Chem Biol Interact 169: 32-41   DOI   ScienceOn
54 Choi JW, Sohn KH, Kim SH. 1991. Effects of nicotinamide on the serum lipid composition in streptozotocin-induced diabetic rats. J Korean Soc Food Nutr 20: 306-311   과학기술학회마을
55 Bursch W, Schulte-Hermann R. 1986. Cytoprotective effect of the prostacyclin derivative iloprost against liver cell death induced by the hepatotoxins carbon tetrachloride and bromobenzen. Klin Wochenschr 64: 47-50
56 Browinlee N, Vlassara H, Cerami A. 1984. Nonenzymatic glycosylation and the pathogenesis of diabetic complication. Ann Intern Med 101: 527-537   DOI   ScienceOn
57 Siegel RD, Cuples A, Schaefer EJ, Wilson PWF. 1996. Lipoproteins, apolipoproteins, and low-density lipoprotein size among diabetics in the Framingham offspring study. Metabolism 45: 1267-1272   DOI   ScienceOn
58 You JS, Chang KJ. 1998. Effects of taurine supplementation on lipid peroxidation, blood glucose and blood lipid metabolism in streptozotocin-induced diabetic rats. Adv Exp Med Biol 442: 163-168   DOI
59 Kim SH, Ryu DS, Lee MY, Kim KH, Kim YH, Lee DS. 2008. Anti-diabetic activity of polysaccharide from Salicornia herbacea. Korean J Microbiol Biotechnol 36: 43-48   과학기술학회마을