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http://dx.doi.org/10.3746/jkfn.2009.38.6.667

Antihyperlipidemic and Glycemic Control Effects of Mycelia of Inonotus obliquus Including Protein-bound Polysaccharides Extract in C57BL/6J Mice  

Kim, Min-A (Dept. of Food Science and Human Nutrition, Chonbuk National University)
Jeong, Yong-Seob (Dept. of Biotechnology, Chonbuk National University)
Chun, Gei-Taek (Dept. of Molecular Bioscience, Kangwon National University)
Cha, Youn-Soo (Dept. of Food Science and Human Nutrition, Chonbuk National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.6, 2009 , pp. 667-673 More about this Journal
Abstract
The antihyperlipidemic and glycemic control effects of mycelia of Inonotus obliquus including protein-bound polysaccharides extract were investigated. In high fat diet-induced obese C57BL/6J mice, the mycelia of Inonotus obliquus including protein-bound polysaccharides extract showed significant decrease in epididymal fat tissue weight, blood triglyceride and VLDL level, triglyceride and total cholesterol level in liver, serum insulin and HOMA-IR level and AUC. Oral glucose tolerance test glucose level reduction were 4.9% (M150L; ${\beta}$-glucan 1.303 mg/kg bw), 9.5% (M150; ${\beta}$-glucan 2.606 mg/kg bw) after 180 min of glucose loading compared to H-C group. Besides, the mycelia of Inonotus obliquus including protein-bound polysaccharides extract treatment significantly increased glycogen contents in liver and adiponectin level in high fat diet-induced obese mice. In conclusion, the results showed that the mycelia of Inonotus obliquus including protein-bound polysaccharides extract possesses significant antihyperlipidemic and glycemic control effects in C57BL/6J mice.
Keywords
Inonotus obliquus; mycelia; protein bound polysaccharides; anti-hyperlipidemic effect; glycemic control;
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Times Cited By KSCI : 9  (Citation Analysis)
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