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http://dx.doi.org/10.3746/jkfn.2009.38.5.644

Antiproliferative Effect of Bacillus subtilis Fermented Soy Milk in AGS Human Gastric Adenocarcinoma Cells  

Seo, Hae-Ree (Dept. of Food Science and Nutrition, Pusan National University)
Kim, Ji-Young (Dept. of Food Science and Nutrition, Pusan National University)
Bae, Geun-Ho (Chunho Food Company)
Park, Kun-Young (Dept. of Food Science and Nutrition, Pusan National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.5, 2009 , pp. 644-648 More about this Journal
Abstract
Antiproliferative effects of soy milk fermented with Bacillus subtilis from chungkukjang was studied in AGS human gastric adenocarcinoma cells. The fermented soy milk by B. subtilis (B. subtilis-F-SM) exhibited 82% growth inhibitory effect at 2 mg/mL concentration, while non-fermented soy milk (Non-F-SM) showed 68%. B. subtilis-F-SM treated AGS cells induced more apoptotic bodies than the Non-F-SM treated cells. In mRNA expressions, B. subtilis-F-SM showed decreased expression of anti-apoptotic bcl-2 and increased expression of pro-apoptotic bax. The expressions of tumor suppressor genes of p53 and p21 were also increased. These results suggest that fermented soy milk by B. subtilis exhibited higher antiproliferative activities compared with non-fermented soy milk.
Keywords
soy milk; Bacillus subtilis; anticancer;
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Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By SCOPUS : 1
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