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http://dx.doi.org/10.3746/jkfn.2009.38.12.1718

Hemopoietic Effect of Extracts from Four Parts of Deer Antler on Phenylhydrazine-Induced Hemolytic Anemia in Female Rats  

Lee, Mi-Ra (Dept. of Food Science and Technology, Chungnam National University)
Kim, Hyun-Ho (Dept. of Food Science and Technology, Chungnam National University)
Jo, Hyun-Ho (Dept. of Food Science and Technology, Chungnam National University)
Kang, Hyo-Jin (Dept. of Food Science and Technology, Chungnam National University)
Gu, LiJuan (Dept. of Food Science and Technology, Chungnam National University)
Ly, Sun-Young (Dept. of Food and Nutrition, Chungnam National University)
Lee, Chung-Ha (DBIO Research Institute)
Kim, Seung-Mi (DBIO Research Institute)
Yang, Sun-Ah (DBIO Research Institute)
Mo, Eun-Kyung (DBIO Research Institute)
Sung, Chang-Keun (Dept. of Food Science and Technology, Chungnam National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.12, 2009 , pp. 1718-1723 More about this Journal
Abstract
This study was to investigate the protection of the extracts from four parts of deer antler in an anemia model induced by intravenous injection of phenylhydrazine·HCl (PHZ) at 10 mg/kg for 4 days. After PHZ injection, female Sprague-Dawley rats were administrated partial deer antler extract (200 mg/kg/day, p.o.) daily for 1 week. Results showed that sever hemolysis was induced by PHZ. For antler extract-treated groups, the concentration of hemoglobin, hematocrit and red blood cells number increased much more significantly than PHZ-treated group. Upper antler extract-treated group was more remarkable than other parts in suppressing the increase of reticulocyte in whole blood. Moreover, antler extract administration significantly improved serum erythropoietin concentration. The activity of $\delta$-aminolevulinic acid dehydrates (ALAD) in liver homogenate was increased in antler extract-treated groups, especially middle and base extract-treated groups showed statistical significance. These results could be concluded that the deer antler extract improved anemia induced by PHZ injection through improving hematological values, serum EPO value, ALAD enzyme activity.
Keywords
phenylhydrazine; anemia; deer antler; hemopoietic effect;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 1
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