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http://dx.doi.org/10.3746/jkfn.2009.38.11.1516

Effects of Oenanthe javanica, Coicis lachryma-jobi L. var., and Plantaginis asiatica L. Water Extracts on Activities of Key Enzymes on Lipid Metabolism  

Lee, Hyeon-Ju (Dept. of Plant Biotechnology, Division of Biotechnology, School of Bioscience and Biotechnology)
Chung, Mi-Ja (The Nutraceutical Bio Brain Korea 21 Project Group, Kangwon National University)
Kim, Dae-Jung (Dept. of Plant Biotechnology, Division of Biotechnology, School of Bioscience and Biotechnology)
Choe, Myeon (Dept. of Plant Biotechnology, Division of Biotechnology, School of Bioscience and Biotechnology)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.11, 2009 , pp. 1516-1521 More about this Journal
Abstract
This study was carried out to estimate beneficial effects of medicinal plant [Oenanthe javanica (MNR), Coicis lachryma-jobi L. var. (YM), Plantaginis asiatica L. (CJJ)] water extracts on activities of key enzymes such as lipoprotein lipase (LPL), acyl-CoA synthetase (ACS) and carnitine acetyltransferase (CAT) on lipid metabolism. LPL and ACS were extracted from the epididymal adipose tissue and liver of Zucker lean rats (lean) and Zucker fatty rats (fa/fa). MNR or YM water extract treatment significantly reduced the activity of lean and fa/fa LPL. When 10000 ppm of MNR, YM, and CJJ water extracts were tested, they decreased fa/fa LPL activity by 32.5%, 30.1% and 22.8%, respectively. The lean ACS activity was significantly higher in YM water extract treatment compared to the control and the MNR water extract treatment significantly increased the activity of fa/fa ACS, compared to the activity in the control (p<0.05). MNR water extract activated fa/fa ACS activity by 12-fold compared with control at 10000 ppm concentration. CAT activity was significantly higher in 10000 ppm and 20000 ppm CJJ water extract treatment than in the control. Thus, the MNR, YM and CJJ water extracts may have beneficial effects due to activities of enzymes related with fat metabolism in obese humans.
Keywords
obesity; acyl-CoA synthetase; lipoprotein lipase; carnitine acetyl transferase; medicinal plant;
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1 Whang T.E, Lim H.O, Lee J.W. 1999. Effect of fermented (Oenanthe javanica D.C.) extract on the activity of enzymes related to liver function of alcohol-administered rats and mice. Kor J Medicinal Crop Sci 7: 107-114
2 Kang B.S, Won H.J, Hahm Y.T, Kim H.K, Kim B.Y. 2000. Effects of extruded job's tear cereal on lipid metabolism in high fat fed rats. J Korean Soc Food Sci Nutr 29: 252-256
3 Carlo B, Fabio D. 1982. Assignment of correct structure to two tetra hydrodideoxy aucubins. J Org Chem 47: 1343-1352   DOI
4 Mead J.R, Irvine S.A, Ramji D.P. 2002. Lipoprotein lipase: structure, function, regulation, and role in disease. J Mol Med 80: 753-769   DOI   ScienceOn
5 Burns A.A, Livingstone M.B, Welch R.W, Dunne A, Rowland I.R. 2002. Dose response effects of a novel fat emulsion (Oliibra) on energy and macronutrient intakes up to 36 h post-consumption. Eur J Clin Nutr 56: 368-377   DOI   ScienceOn
6 Choi M.K, Kim M.H, Lee Y.S, Cho H.K, Kim K.H, Lee B.B, Sung M.K, Sung C.J. 2005. Relation between obesity indices and, nutritional knowledge, nutritional status and blood parameters in obese middle-school students. J Korean Soc Food Sci Nutr 34: 181-189   과학기술학회마을   DOI   ScienceOn
7 Kim M.H. 2004. Updates in treating obesity. Korean J Health Psychol 9: 493-959
8 Reddy P, Chow M.S.S. 1998. Focus on orlistat: A non-systemic inhibitor of gastrointestinal lipase for weight reduction in the management of obesity. Formulary 33: 943-959
9 Zacour A.C, Sliva M.E, Cecon P.R, Bambirra E.A, Vieira E.C. 1992. Effect of dietary chitin on cholesterol absorption and metabolism in rats. J Nutr Sci Vitaminol 38: 609-613   DOI   ScienceOn
10 Son M.J, Cha C.G, Park J.H, Kim C.S, Lee S.P. 2005. Manufacture of dropwort extract using brown sugar, fructose syrup and oligosaccharides. J Korean Soc Food Sci Nutr 34: 1485-1489   과학기술학회마을   DOI   ScienceOn
11 Lee H.Y, Yoo M.J, Chung H.J. 2001. Antibacterial activities in watercress (Oenanthe javanica D.C.) cultivated with different culture methods. Kor J Food Culture 16: 243-249   과학기술학회마을
12 Gomita Y, Ichimaru Y, Moriyama M, Fukamachi K, Uchikado A, Araki Y, Fukuda T, Koyama T. 1981. Behavioral and EEG effects of coixol (6-methoxy benzoxazolone), one of the components in Coix lachryma-jobi L. var. ma-yuen Stapf. Folia Pharm Japan 77: 245-259   DOI   ScienceOn
13 Cho S.Y, Kim M.J. 1995. The effect of plantaginis semen on serum and hepatic lipid metabolism in fed high and low fat diets. J Korean Soc Food Nutr 24: 517-522   과학기술학회마을
14 Shimizu S, Inoue K, Tani Y, Yamada H. 1979. Enzymatic microdetermination of serum free fatty acids. Anal Biochem 98: 341-345   DOI   ScienceOn
15 Takahashi M, Konno C, Hikino H. 1986. Isolation and hypoglycemic activity of Coixans A, B and C, glycans of Coix lachryma-jobi L. var. ma-yuen seeds. Planta Med 52: 64-65   DOI   ScienceOn
16 Shin D.K, Park C.H, Lee Y.J, Lee Y.O. 1990. The effect of Job's tear diet on change of body lipid and tissue in rat. Kor J Oil Chem 7: 83-90
17 Park J, Yang M, Jun H.S, Lee J.H, Bae H.K, Park T. 2003. Effect of raw brown rice and Job's tear supplemented diet on serum and hepatic lipid concentrations, antioxidative system and immune function of rats. J Korean Soc Food Sci Nutr 32: 197-206   DOI   ScienceOn
18 Kwak C.S, Lim S.J, Kim S.A, Park S.C, Lee M.S. 2004. Antioxidative and antimutagenic effects of Korean buckwheat, sorghum, millet and Job's tears. J Korean Soc Food Sci Nutr 33: 921-929   DOI   ScienceOn
19 Chung I.M, Yun H.S, Kim Y.S, Ahn J.W. 1984. Aucubin potential antidote for $\alpha$amanitin poisoning. J Tox Clin Tox 22: 77-85   DOI
20 Miyazawa S, Hashimoto T, Yokota S. 1985. Identity of ling chain acyl-CoA synthetase of microsomes, mitochondria and peroxisomes in rat liver. J Biochem 98: 732-733
21 Quinn D.M, Shirai K, Jackson R.L, Harmony J.K. 1982. Lipoprotein lipase catalyzed hydrolysis of water soluble p-nitrophenyl esters. Inhibition by apolipoprotein C-II. Biochemistry 21: 6872-6879   DOI   ScienceOn
22 Ryu M.H, Daily J.W, Cha Y.S. 2005. Effect of starvation on hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats. Nutrition 21: 537-542   DOI   ScienceOn
23 Joo C.N, Kim S.J. 1994. Effect of ginseng components (ginsenosides and fat soluble fraction) on rat liver glucokinase activity. Korean J Ginseng Sci 18: 17-24   과학기술학회마을
24 Oh H.T, Chung M.J, Kim S.H, Choi H.J, Ham S.S. 2009. Masou salmon (Oncorhynchus masou) ethanol extract decrease 3-hydroxy-3-methylglutarylcoenzyme A reductase expression in diet-induced obese mice. Nutr Res 29: 123-129   DOI   ScienceOn
25 Eckel R.H. 1989. Lipoprotein lipase: A multifunctional enzyme relevant to common metabolic diseases. New Eng J Med 320: 1060-1067   DOI   ScienceOn
26 Lee J.J, Choe M.S, Chung C.S, Choe B. 2003. Effect of food restriction on rat adipotise tissue lipoprotein lipase activity and lipogenesis. Kor J Exercise Nutr 7: 135-141
27 Cha Y.J, Lee S.Y. 2005. Cytotoxicity and multiding-resistance reversing activity of extracts from gamma-irradiated Coix lachryma-jobi L. var. ma-yuen stapf seed. J Korean Soc Food Sci Nutr 34: 613-618   과학기술학회마을   DOI   ScienceOn
28 Bergmeyer H.U, Gawehn K, Grassl M. 1974. Enzymes as biochemical reagents. In Methods of Enzymatic Analysis. Bergmeyer HU, ed. Academic Press, New York, NY, USA. Vol Ⅰ, p 438-444
29 Otsuka H, Hirai Y, Nagao T, Yamasaki K. 1988. Anti-inflammatory activity of benzoxanoids from roots of Coix lachryma-jobi L. var. ma-yuen. J Nat Prod 51: 74-79   DOI
30 Chiu K.M, Schmidt M.J, Shug A.L, Binkley N, Gravenstein S. 1997. Effect of dehydroepiandrosterone sulfate on carnitine acetyl transferase activity and L-carnitine levels in oophorectomized rats. Biochim Biophys Acta 1344: 201-209   DOI   ScienceOn
31 McGarry J.D, Brown N.F. 1997. The mitochondrial carnitine palmitoyltransferase system: from concept to molecular analysis. Eur J Biochem 244: 1-14   DOI   ScienceOn
32 Choe M, Kim D.J, Lee H.J, You J.K, Seo D.J, Lee J.H, Chung M.J. 2008. A study on the glucose-regulating enzymes and antioxidant activities of water extracts from medicinal herbs. J Korean Soc Food Sci Nutr 37: 542-547   과학기술학회마을   DOI   ScienceOn
33 Naderali E.K. 2009. Obesity and cardiovascular dysfunction: A role for resveratol? Obes Res Clin Pract 3: 45-52.   DOI   ScienceOn
34 Numata M, Yamamoto A, Moribayash A, Yamada H. 1994. Antitumor components isolated from the Chinese herbal medicine Coix lachryma-jobi. Planta Med 60: 356-359   DOI   ScienceOn
35 Ahn I.S, Park K.Y, Do M.S. 2007. Weight control mechanisms and antiobesity functional agents. J Korean Soc Food Sci Nutr 36: 503-513   과학기술학회마을   DOI   ScienceOn
36 McGarry J.D, Foster D.W. 1980. Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 49: 395-420   DOI   ScienceOn