Browse > Article
http://dx.doi.org/10.3746/jkfn.2009.38.10.1289

Antiinflammatory Effect of Aqueous Extract from Red Pepper on Lipopolysaccharide Induced Inflammatory Responses in Murine Macrophages  

Kwon, Hyuck-Se (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Shin, Hyun-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Kwon, Sang-O (S&D Co., Ltd)
Yeo, Kyung-Mok (S&D Co., Ltd)
Kim, Sang-Moo (S&D Co., Ltd)
Kim, Bok-Nam (Dept. of Tourism and Food Service Cuisine, Hallym College)
Kim, Jin-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.10, 2009 , pp. 1289-1294 More about this Journal
Abstract
Inflammation is a pivotal component of a variety of diseases, such as atherosclerosis and tumour progression. Various naturally occurring phytochemicals exhibit antiinflammatory activity and are considered to be potential drug candidates against inflammation-related pathological processes. Red pepper is the most consumed species in Korea. However, the antiinflammatory effects of red pepper have not been characterized. Thus, the present study was designed to evaluate the effects of the aqueous extract from red pepper (RPAE) on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages. RPAE demonstrated strong antiinflammatory activity through its ability to reduce nitric oxide and prostaglandin $E_2$ production in the LPS-stimulated mouse macrophage cell, RAW264.7. It also inhibited the production of interleukin-6 (IL-6) on the LPS-stimulated RAW264.7 cells. Further study indicated that LPS-stimulated induction of inducible nitric oxide synthase and cyclooxygenase-2 was significantly inhibited by RPAE exposure (1,000 mg/mL) in RAW264.7 cells. Collectively, these data suggest that the use of RPAE may be a useful therapeutic approach to various inflammatory diseases.
Keywords
red pepper; inflammation; nitric oxide; prostarglandin $E_2$; interlukine-6;
Citations & Related Records

Times Cited By SCOPUS : 1
연도 인용수 순위
  • Reference
1 Willeaume V, Kruys V, Mijatovic T, Huez G. 1996. Tumor necrosis factor-alpha production induced by viruses and by lipopolysaccharide in macrophages: similarities and differences. J Inflamm 46: 1-12.
2 Diepvens K, Westerterp KR, Westerterp-Plantenga MS. 2007. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 292: R77-85.   DOI
3 Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Segawa K, Ikeda Y, Kizaki M. 2004. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: Implication of phosphorylation of p53 at ser-15 residue by reactive oxygen species. Cancer Res 64: 1071-1078.   DOI   ScienceOn
4 Lawrence T, Wiilloughby DA, Gilroy DW. 2002. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol 2: 787-795.   DOI   ScienceOn
5 Kim CS, Kawada T, Kim BS, Han IS, Choe SY, Kurata T, Yu R. 2003. Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages. Cell Signal 15: 299-306.   DOI   ScienceOn
6 Mori A, Lehmann S, O'Kelly J, Kumagai T, Desmond JC, Pervan M, McBride WH, Kizaki M, Koeffler HP. 2006. Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res 66: 3222-3229.   DOI   ScienceOn
7 Park JY, Kawada T, Han IS, Kim BS, Goto T, Takahashi N, Fushiki T, Kurata T, Yu R. 2004. Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand- like action as a novel mechanism. FEBS Lett 572: 266-270.   DOI   ScienceOn
8 Oboh G, Rocha JB. 2008. Hot pepper (Capsicum spp.) protects brain from sodium nitroprusside- and quinolinic acid-induced oxidative stress in vitro. J Med Food 11: 349-355.   DOI
9 Palevitch D, Craker LE. 1995. Nutritional and medicinal importance of red pepper (Capsicum spp.). J Herbs Spices Med Plants 3: 55-83.
10 Kim JD, Kim JM, Pyo JO, Kim SY, Kim BS, Yu R, Han IS. 1997. Capsaicin can alter the expression of tumor forming- related gene which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1. Cancer Lett 120: 235-241.   DOI   ScienceOn
11 Tizard IR. 1986. Immunology: an introduction inflammation. 2nd ed. Saunders College Pubulishing, New York, NY, USA. p 423-441.
12 Higuchi M, Hisgahi N, Taki H, Osawa T. 1990. Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages. J Immunol 144: 1425-1431.
13 Iontcheva I, Amar S, Zawawi KH, Kantarci A, Van Dyke TE. 2004. Role for moesin in lipopolysaccharide-stimulated signal transduction. Infect Immun 72: 2312-2320.   DOI
14 Baud V, Karin M. 2001. Signal transduction by tumor necrosis factor and its relatives. Trend Cell Biol 11: 372-377.   DOI   ScienceOn
15 Kang SN, Chung SW, Kim TS. 2001. Capsaicin potentiates 1,25-dihydoxyvitamin $D_3-$ and ATRA-induced differentiation of human promyelocytic leukemia HL-60 cells. Eur J Pharmacol 420: 83-90.   DOI   ScienceOn
16 Daood HG, Vinkler M, Markus F, Hebshi EA, Biacs PA. 1996. Antioxidant vitamin content of spice red pepper (paprika) as affected by technological and varietal factors. Food Chem 55: 365-372.   DOI   ScienceOn
17 Krinsky NI. 2001. Carotenoids as antioxidants. Nutrition 17: 815-817.   DOI   ScienceOn
18 Matucci CM, McCarthy G, Lombardi A, Pignone A, Partsch G. 1995. Neurogenic influences in arthritis: potential modification by capsaicin. J Rheumatol 22: 1447-1449.
19 Zhang J, Nagasaki M, Tanaka Y, Morikawa S. 2003. Capsaicin inhibits growth of adult T-cell leukemia cells. Leuk Res 27: 275-283.   DOI   ScienceOn
20 Laflamme N, Rivest S. 2001. Toll-like receptor 4: The missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J 15: 155-163.   DOI   ScienceOn
21 Watson CP, Evans RJ, Watt VR. 1988. Post-herpetic neuralgia and topical capsaicin. Pain 33: 333-340.   DOI   ScienceOn
22 Krinsky NI. 1994. The biological properties of carotenoids. Pure Appl Chem 66: 1003-1010.   DOI   ScienceOn
23 Sicuteri F, Fusco BM, Marabini S, Campagnolo V, Maggi CA, Geppetti P, Fanciullacci M. 1989. Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain 5: 49-53.   DOI