Isolation of Cucurbitacin E from Sprouted Pumpkin Seed and Analysis of Its Anti-cancer and Anti-inflammatory Activities |
Sim, Hu-Sung
(Dept. of Food Science & Technology, Chungnam National University)
Jang, Byeong-Chur (Dept. of Medical Genetic Engineering, School of Medicine, Keimyung University) Park, Hye-Min (Dept. of Food Science & Technology, Chungnam National University) Jeng, Byeong-Yong (Sangsaeng Food Company) Oh, Man-Jin (Dept. of Food Science & Technology, Chungnam National University) |
1 | Enslin PR. 1954. Bitter principles of the cucurbitaceae-Observations on the chemistry of cucurbitacin A. J Sci Food Agric 5: 410-416 DOI |
2 | Lavie D, Szinai S. 1958. The constituents of Ecballium elaterium L. J Am Chem Soc 80: 707-710 DOI |
3 | Duncan MD, Duncan KL. 1997. Cucurbitacin E targets proliferating endothelia. J Surg Res 69: 55-60 DOI ScienceOn |
4 | Attard E, Cuschieri A, Brincat MP. 2005. Morphological effects induced by Cucurbitacin E on ovarian cancer cells in vitro. J Natural Remedies 5: 70-74 |
5 | Kimberly LKD, Mark DD, Michael CA, Edward AS. 1996. Cucurbitacin E induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells. Biochem Pharmacol 52: 1553-1560 DOI ScienceOn |
6 | Peters RR, Saleh TF, Lora M, Patry C, de Brum-Fernandes AJ, Farias MR, Ribeiro-do-Valle RM. 1999. Anti-inflammatory effects of the products from Wildbrandia ebracteata on carragennan-induced pleurisy in mice. Life Sci 64: 2429-2435 DOI ScienceOn |
7 | Lee BJ, Jang HS, Lee GH, Oh MJ. 2003. Changes in chemical compositions of pumpkin (Cucurbita moschata Duch.) seed sprouts. Korean J Food Preservation 10: 527-533 과학기술학회마을 |
8 | Tehila TS, Shlomo G, Sara D, Hugo EG, Margalit B. 2007. Growth inhibitory activity of cucurbitacin glucosides isolated form citrullus colocynthis on human breast cancer cells. Biochem Pharmacol 73: 56-67 DOI ScienceOn |
9 | Charmichael J, Degraff WG, Gazdar AF, Minna JD, Michell JB. 1987. Evaluation of tetrazolium based semiautomated colorimetric assay, assessment of chemosensitivity testing. Cancer Res 47: 963-972 |
10 | Jayaprakasam B, Seeram NP, Nair MG. 2003. Anticancer and antiflammatory activities of cucurbitacins from Cucurbita andrena. Cancer Lett 189: 11-16 DOI ScienceOn |
11 | Miro M. 1995. Cucurbitacin and their pharmacological effect. Phyto Res 9: 159-168 DOI ScienceOn |
12 | Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. 2003. A selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 63: 1270-1279 |
13 | Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM. 2005. Cucurbitacin Q: a selective START 3 activation inhibitor with potent antitumor activity. Oncogene 24: 3236-3245 DOI ScienceOn |
14 | Raloff J. 1999. The bitter end. Science News 156: 24-30 DOI |
15 | Terrence FH, Mark EH. 1985. The determination of bitter principles in Zuccjinis. J Sci Food Agric 36: 1107-1112 DOI |
16 | Cardellina JH, Gustafson KR, Beutler JA, He-Kee C, Hallock YF, Fuller RW, Boyd MR. 1990. Human medicinal agents form plant. American Chemical Society, Washington DC, 218-227 |
17 | Dulcie AM. 1997. Cucurbitacin triterpenoids from the leaves of Momodica foetida. Phytochemistry 45: 391-395 DOI ScienceOn |
18 | Fathi TH. 1998. Production of cucurbitacin by cucurbit cell cultures. Plant Sci 13: 209-214 |
19 | Robinson RW, Munger HM, Whitaker TW, Bohn GW. 1976. Genes of the Cucurbitaceae. Hort Science 11: 554-568 |
20 | Rehm S. 1960. Die bitter stoffe der cucurbitaceen. Ergeb Biol 22: 106-136 |