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http://dx.doi.org/10.3746/jkfn.2008.37.6.696

Genotoxicological Safety of Octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate from Gallic and Linoleic Acids and Its Biological Functions in Cream-based Emulsion  

Jung, Sa-Moo-El (Dept. of Animal Science & Biotechnology, Chungnam National University)
Song, Hyun-Pa (Dept. of Animal Science & Biotechnology, Chungnam National University)
Lee, Na-Young (Dept. of Food Science and Biotechnology, Chonbuk National University)
Jang, Ae-Ra (Quality Control and Utilization Division, National Institute of Animal Science, RDA)
Jo, Cheo-Run (Dept. of Animal Science & Biotechnology, Chungnam National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.37, no.6, 2008 , pp. 696-700 More about this Journal
Abstract
The objective of this study was to investigate the genotoxicological safety and biological functions of octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate (GA-LA) in cream-based emulsion for future application as a functional cosmetic material as well as food. GA-LA was synthesized chemically from gallic acid and linoleic acid. The Ames test showed that GA-LA did not have mutagenical toxicity. The control cream-based emulsion containing GA-LA was prepared by commercial method and tested for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Ferric reducing antioxidant power (FRAP) and inhibition effect against tyrosinase of the emulsions were tested for the evaluation of antioxidative and skin-whitening activities. The results showed that DPPH radical scavenging activity in the cream-based emulsion containing GA-LA was higher (52.65%) than that of the control (4.30%). The FRAP value of the sample was 12.85%, however, no activity was found in control. The inhibition effect of tyrosinase showed also a higher value (26.29%) when compared to the control. The results indicate that GA-LA, which showed superior antioxidative and skin-whitening activities in cream-based emulsion, is a useful functional material applicable in cosmetic products as well as food.
Keywords
octadeca-9,12-dienyl-3,4,5-trihydroxybenzoate; antioxidative; skin-whitening; genotoxicological safety;
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