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http://dx.doi.org/10.3746/jkfn.2008.37.11.1389

Antioxidative and Hepatoprotective Effects of Acer tegmentosum M. Extracts  

Kwon, Ha-Na (Dept. of Food and Nutrition, Yeungnam University)
Park, Jyung-Rewng (Dept. of Food and Nutrition, Yeungnam University)
Jeon, Jeong-Ryae (Dept. of Food and Nutrition, Yeungnam University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.37, no.11, 2008 , pp. 1389-1394 More about this Journal
Abstract
This study was carried out to investigate antioxidative and hepatoprotective effects of Acer tegmentosum M. (ATM) extracts. Content of total polyphenol of EtOAc fraction was the highest amount among fractions. Electron donating abilities of all fractions were increased as concentrations of each fraction were increased. ATM BuOH fraction showed the highest SOD like activity at low concentration (<$250\;{\mu}g/mL$). To investigate the protective effect of ATM on hepatotoxicity, ATM BuOH fraction was administered to mice for 7 consecutive days, and then lipopolysaccharide (LPS) was injected at a dosage of 1 mg/kg. The LPS led to increase of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and blood urea nitrogen (BUN). However, pretreatment with BuOH fraction prior to LPS injection significantly decreased plasma hepatospecific enzyme levels. Histological findings demonstrated that pretreatment with BuOH fraction resulted in an attenuation of LPS induced liver damages.
Keywords
Acer tegmentosum M.; antioxidative; hepatotoxicity; lipopolysaccharide;
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