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http://dx.doi.org/10.3746/jkfn.2007.36.7.832

Effects of Supplemental Agents Enhancing Calcium Absorption on Bioavailability of Starfish Calcium in Rats  

Moon, Ji-Young (Dept. of Food and Nutrition, Research Institute of Human Ecology, Seoul National University)
Jang, Soo-Jung (Dept. of Food and Nutrition, Research Institute of Human Ecology, Seoul National University)
Park, Mi-Na (Dept. of Food and Nutrition, Research Institute of Human Ecology, Seoul National University)
Park, Hee-Yeon (Biotechnology Research Center NFRDI)
Lee, Yeon-Sook (Dept. of Food and Nutrition, Research Institute of Human Ecology, Seoul National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.7, 2007 , pp. 832-839 More about this Journal
Abstract
This study was conducted to investigate the bioavailability of starfish calcium with substances enhancing calcium absorption. Three week-old young female rats (Sprague-Barley) were divided into 5 groups according to calcium sources and testing agents; calcium carbonate (C), starfish calcium (S), starfish calcium + casein phosphopeptide (S-CPP), starfish calcium+citrate-malate (S-CM), starfish calcium+isoflavone (S-ISO), and were fed experimental diets containing AIN-93G based Ca (0.35% w/w) diet with CPP, CM and ISO for 6 weeks. Blood, femur, urine and feces samples were collected. There was no significant difference among groups in terms of growth and food intake. Serum Ca concentrations were normal in all 5 groups. Serum P concentrations and ALP activities were not significantly different among groups. Ca absorption and retention were significantly increased both in S-CPP and S-CM groups compared to C group (p<0.05). p absorption was significantly higher in S-CPP group than in other groups. While the amount of soluble Ca of intestinal contents did not differ among groups, the amount of insoluble Ca was significantly lower in S-CPP, S-CM and S-ISO groups than in C and S groups. However, the weight, Ca and P concentrations of femur were not significantly different among groups. These results suggest that the addition of CPP and citrate-malate were more effective for enhancing the bioavailability, intestinal absorption and solubility of starfish calcium.
Keywords
starfish calcium; calcium bioavailability; casein phosphopeptide; citrate-malate; isoflavone;
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