Browse > Article
http://dx.doi.org/10.3746/jkfn.2007.36.4.439

Effects of Long-Term Administration of Saengshik on Growth Increment, BMD and Blood IGF-1 Concentration in Growing Rats  

Kim, Joong-Hark (Erom R&D Center)
Hong, Sung-Gil (Erom R&D Center)
Kim, Wha-Young (Erom R&D Center)
Jung, Ji-Sang (Erom R&D Center)
Hwang, Sung-Ju (Erom R&D Center)
Mok, Chul-Kyoon (Dept. of Food and Bioengineering, Kyungwon University)
Park, Mi-Hyoun (Erom R&D Center)
Lee, Ju-Yeon (Erom R&D Center)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.4, 2007 , pp. 439-446 More about this Journal
Abstract
This study was performed to investigate the effect of long-term administration of Saengshik on growth parameters of growing rats. Male Sprague-Dawley rats were fed on AIN-93G basal diets for 12 weeks and assigned to the following groups: rats administrated orally with Saengshik at the dose of 1g/kg/day (1xJS ), 2g/kg/day (2xJS), 4g/kg/day (4xJS) and distilled water (Control). Rats were sacrificed at 4, 8, 12 weeks after oral administration. Bone mineral density (BMD) and bone mineral contents (BMC) were measured by PIXImus densitometry and serum insulin-like growth factor-1 (IGF-1) concentration were determined by using EIA method. Body weight and food intake did not show significant changes within groups for 12 weeks. Physical longitudinal growth indexes, body length and femur length were significantly increased in Saengshik-administered groups at 12 weeks, in which BMD and BMC also significantly increased. Also, in blood IGF-1 level, Saengshik-administered groups were remarkedly higher than control group at 4 week (p<0.001), in which significantly higher at 8 week and 12 week. These results suggest a close relation between administration of Saengshik and increment of longitudingal bone growth. Therefore, as the result of this study, it could be expected that the administration of Saengshik for 12 weeks is helpful to the increase of longitudinal growth and growth factors in rats. Furthermore, we propose that the consumption of Saengshik as dietary supplementation may promote to increase in longitudinal bone growth in growing children.
Keywords
Saengshik; growth; BMD; BMC; IGF-1;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Chung YJ, Han JI. 2000. Prevalence of obesity, living habits and parent's characteristics of 5th grade elementary school boys in Taejon city. Kor J Nutr 33: 421-428   과학기술학회마을
2 Ries CP, Kline K, Weaver SO. 1987. Impact of commercial eating on nutrient adequacy. J Am Diet Assoc 87: 463-468
3 Leem KH, Jeon H. 2001. Effect of Dipsacus asper on the growth of longitudinal bone in adolescent male rats. Korean J Oriental Physiology & Pathology 15: 983-988
4 Jung DY, Lee HY, Ha HK, Jung DY, Kang SS, Kim CS. 2003. Induction of growth hormone release by the extracts of Lonicera japonica Thunb. Kor J Phamacogn 34: 256-262   과학기술학회마을
5 Kang BH, Son HY, Ha CS, Lee HS, Song SW. 1995. Reference values of hematology and serum chemistry in Ktc: Sprague-Dawley rats. Korean J Lab Ani Sci 11: 141-145
6 Nystrom FH, Ohman PK, Ekman BA, Osterlund MK, Karlberg BE, Arnqvist HJ. 1997. Population-based reference values for IGF-I and IGF-binding protein-1: relations with metabolic and anthropometric variables. Eur J Endocrinol 136: 165-172   DOI
7 Jones JI, Clemmons DR. 1995. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16: 3-34   DOI
8 Pfeilshifter J, Erdmann J, Storch S, Ziegler R, Weinreb M. 1999. Change in the concentration of insulin-like growth factor I and transforming growth factor beta1 in rat femoral bone during growth. Calcif Tissue Int 64: 78-82   DOI   ScienceOn
9 Lee YJ, Lee HM, Park TS. 2003. Effects of uncooked powdered food on antioxidative system and serum mineral concentrations in rats fed unbalanced diet. Kor J Nutr 346: 898-907   과학기술학회마을
10 Song MK, Hong SG, Hwang SJ. 2003. Improve effects of Saengshik on patient with fatty liver and hyperlipidemia in murine. Kor J Nutr 36: 834-840   과학기술학회마을
11 Paeratakul S, Ferdinand DP, Champagne CM, Ryan DH, Bray GA. 2003. Fast-food consumption among US adults and children: dietary and nutrient intake profile. J Am Diet Assoc 103: 1332-1338   DOI   ScienceOn
12 Han JH, Park SH. 2003. The effects of uncooked powdered food on nutrient intake, body fat and serum lipid composition in hyperlipidemic patients. Kor J Nutr 36: 589-602   과학기술학회마을
13 Audi L, Vargas DM, Gussinye M, Yeste D, Marti G, Carrascosa A. 2002. Clinical and biochemical determinants of bone metabolism and bone mass in adolescent female patients with anorexia nervosa. Pediatr Res 51: 497-504   DOI   ScienceOn
14 Lyu ES, Kwak TK. 1989. Consumer opinions on fast foods and food service. Korean J Dietary Culture 4: 229-236   과학기술학회마을
15 Kim HK. 1999. Fast food consumption patterns of elementary school children. J Human Ecology 1: 55-68
16 Lee KH, Hwang KJ, Her ES. 2001. A study on body image recognition, food habits, food behaviors and nutrient intake according to the obesity index of elementary children in Changwon. Korean J Community Nutrition 6: 557-591   과학기술학회마을
17 Choi MJ, Yoon JS. 2003. The effect of eating habits and nutrient intake on the physical growth indices in preschool children. Korean J Community Nutrition 8: 3-14   과학기술학회마을
18 Kim SE. 1993. Impact of fast food on balanced nutrients intake among Korean young generation. Part 1. KOSEF 911-1509-079-2
19 Leem KH, Kim HC. 2001. Effect of Cibotium baromets on the growth of longitudinal bone in adolescent male rats. Kor J Herbololgy 16: 49-55
20 Park SY, Leem KH, Kim HC. 2003. Effects of Acanthopanacis Senticosi Radix and its subfractions on longitudinal bone growth of adolescent rats. Kor J Herbololgy 18: 87-92
21 Lee E, Kim WJ, Lee YJ, Lee MK, Kim PG, Park YJ, Kim SK. 2003. Effects of natural complex food on specific enzymes of serum and liver and liver microstructure of rats fed a high fat diet. J Korean Soc Food Sci Nutr 32: 56- 262   과학기술학회마을   DOI
22 Park JS, Park JG, Kim JH, Yu YK, Pyo YH, Lee MG, Sin JH, Hwang SJ, Park MH. 2003. The effect of natural food uptake for 6 months on physical fitness and lipids in blood of athletic player. Korean J Physical Education 42: 883- 893
23 Yang DS, Cha MH, Kang BJ, Oh SW, Kim YE, Yoon YS. 2003. A study on the longitudinal bone growth of growth-stimulating material with Eleutherococcus senticosus. Korean J Food Sci Technol 35: 702-707   과학기술학회마을
24 KFIA. 2005. Food Code. Korea Association Food Industry. p 510
25 Park SH, Han JH. 2003. The effects of uncooked powdered food on nutrient intake, serum lipid level, dietary behavior and health index in healthy women. Kor J Nutr 36: 49-63   과학기술학회마을
26 Park MK. 2006. Strategy for globalization of natural raw meal. Food Industry and Nutrition 11: 10-12   과학기술학회마을
27 Kim ES, Park MH, Hwang SJ, Jeong YH. 2004. Saengshik, a formulated health food, decreases blood glucose and increase survival rate in setreptozotocin-induced diabetic rats. J Med Food 7: 162-167   DOI   ScienceOn
28 Park JY, Yang M, Jung HS, Lee JH, Bae HK, Park TS. 2003. Effect of raw brown rice and Job's tear supplemented diet on serum and hepatic lipid concentration, antioxidative system, and immune function of rats. J Korean Soc Food Sci Nutr 32: 197-206   과학기술학회마을   DOI
29 Kang SM, Shim JY, Hwang SJ, Hong SG, Jang HE, Park MH. 2003. Effects of Saengshik supplementation on health improvement in diet-induced hypercholesterolemic rats. J Korean Soc Food Sci Nutr 32: 906-912   과학기술학회마을   DOI
30 Jang YS, Lee JH, Kim OY, Park HY, Lee SY. 2001. Consumption of whole grain and legume power reduces insulin demand, lipid peroxidation, and plasma homocysteine concentration in patients with coronary artery disease: randomized controlled clinical trial. Arterioscler Thromb Vasc Biol 21: 2065-2071   DOI   ScienceOn
31 Bergmeyer HU, Horder M, Rej R. 1986. Approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2. IFCC Method for aspartate aminotransferase. J Clin Chem Clin Biochem 24: 497-510
32 Gehring KD, Graw M. 2001. Determining body height by the femur and femoral fragments. Arch Kriminol 207: 170-180
33 Bergmeyer HU, Horder M, Rej R. 1986. Approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC Method for alanine aminotransferase. J Clin Chem Clin Biochem 24: 481-495
34 Nagy TR, Clair AL. 2000. Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice. Obes Res 8: 392-398   DOI   ScienceOn
35 Daughaday E, Rotwein P. 1989. Insulin like growth factor I and II. Peptide, messenger ribonucleic acid and gene structures, serum and tissue concentrations. Endocrin Rev 10: 68-91   DOI   ScienceOn
36 Juul A, Bang P, Hertel NT, Main K, Dalgaard P, Jorgensen K, Muller J, Hall K, Skakkebaek NE. 1994. Serum insulin-like growth factor I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J Clin Endocrinol Metab 78: 744-752   DOI
37 Kawai N, Kanzaki S, Takano-Watou S, Tada C, Yamanaka Y, Miyata T, Oka M, Seino Y. 1999. Serum free insulin-like growth factor I (IGF-I), total IGF-I, and IGF-binding protein-3 concentrations in normal children and children with growth hormone deficiency. J Clin Endocrinol Metab 84: 82-89   DOI
38 Rinderknecht E, Humbel RE. 1978. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem 253: 2769-2776
39 Dozmorov I, Bartke A, Miller RA. 2001. Array-based expression analysis of mouse liver genes: effect of age and of the longevity mutant $Prop1^{df}$. J Gerontol A Biol Sci Med Sci 56: B72-80   DOI
40 Kasukawa Y, Baylink DJ, Wergedal JE, Amaar Y, Srivastava AK, Guo R, Mohan S. 2003. Lack of insulin-like growth factor I exaggerates the effect of calcium deficiency on bone accretion in mice. Endocrinology 144: 4682-4689   DOI   ScienceOn
41 Rosen CJ. 2003. Insulin-like growth factor I and calcium balance: evolving concepts of an evolutionary process. Endocrinology 144: 4679-4681   DOI   ScienceOn
42 Laron Z. 2001. Insulin-like growth factor 1 (IGF-1): a growth hormone. Mol Pathol 54: 311-316   DOI
43 Reeves PG, Nielsen FH, Fahey GC Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition and ad hoc writing committee on the reformulation of the AIN-76A diet. J Nutr 123: 1939-1951   DOI
44 Fatayerji D, Eastell R. 1999. Age-related changes in bone turnover in men. J Bone Miner Res 14: 1203-1210   DOI   ScienceOn
45 Corpas E, Harman SM, Blackman MR. 1993. Human growth hormone and human aging. Endocr Rev 14: 20-39   DOI
46 Van Coeverden SC, Netelenbos JC, de Ridder CM, Roos JC, Popp-snijders C, Delemarre-van de Waal HA. 2002. Bone metabolism markers and bone mass in healthy pubertal boys and girls. Clin Endocrinol 57: 107-116   DOI   ScienceOn
47 Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D. 2002. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110: 771-781   DOI   ScienceOn
48 Macdonald HM, Nes SA, Golden MH, Campbell MK, Reid DM. 2004. Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alchol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr 79: 4-5   DOI
49 Penland JG, Sandstead HH, Alcock NW, Dayal HH, Chen XC, Li JS, Zhao F, Yang JJ. 1997. A preliminary report: effects of zinc and micronutrient repletion on growth and neuropsychological function of urban Chinese children. J Am Coll Nutr 16: 268-272   DOI
50 Smith JC, Makdani D, Hegar A, Rao D, Douglass LW. 1999. Vitamin A and zinc supplementation of preschool children. J Am Coll Nutr 18: 213-222   DOI
51 Tylavsky FA, Holliday K, Danish R, Womack C, Norwood J, Carbone L. 2004. Fruit and vegetable intakes are an independent predictor of bone size in early pubertal children. Am J Clin Nutr 79: 311-317   DOI
52 Trucker KL, Chen H, Hannan MT, Cupples LA, Wilson PW, Felson D, Kiel DP. 2002. Bone mineral density and dietary patterns in older adults: the framingham osteoporosis study. Am J Clin Nutr 76: 245-252   DOI
53 Whiting SJ, Vatanparast H, Baxter-Jones A, Faulkner RA, Mirwald R, Bailey DA. 2004. Factors that affect bone mineral accrual in the adolescent growth spurt. J Nutr 134: 696S-700S   DOI
54 Wattanapenpaiboon N, Lukito W, Wahlqvist ML, Strauss BJ. 2003. Dietary carotenoid intake as a predictor of bone mineral density. Asia Pacific J Clin Nutr 12: 467-473