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http://dx.doi.org/10.3746/jkfn.2007.36.4.400

Antitumor Activity of Salvia miltiorrhiza Herbal Extract in Rat Tumor Model  

Park, Hyun-Jeong (College of Oriental Medicine, Dongshin University)
Ahn, Sang-Gun (College of Dentistry, Chosun University)
Kim, Jeong-Sang (College of Oriental Medicine, Dongshin University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.4, 2007 , pp. 400-404 More about this Journal
Abstract
The present study was carried out to investigate the antitumor activity of Salvia miltiorrhiza (SM) herbal extract in rat tumor model. We used a new tumor animal model for the invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras). We observed tumor as early as 7 days after the injection of RK3E-ras cells in subcutaneous of Sprague-Dawley rats. All of the rats developed tumor mass at the inoculated site. After 7 days, the experimental groups were divided into two: saline control and injected with SM (200 mg/kg) groups. We investigated tumor's weight, size and hepatic metastasis of each group. Injection of SM herbal extract every other day for 14 days significantly inhibited tumor growth. Histologically, the tumors were undifferentiated carcinoma showing multifactorial necrosis and hemorrhage; also, the tumor invaded into hepatoportal region. Treatment with SM herbal extract caused significant inhibition of tumor cell proliferation. Our data showed that SM herbal extract is effective in controlling the tendency of tumor cell proliferation and metastasis by injection of RK3E-ras cells. These findings provided the potential value of SM as a novel antitumor agent candidate.
Keywords
Salvia miltiorrhiza; tumor; RK3E-ras cell; rat;
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