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http://dx.doi.org/10.3746/jkfn.2007.36.3.305

Effect of KH-305 on the Nitric Oxide Synthase Activity and Erectile Dysfunction in Young Rats  

Lee, Eun-Jeong (Korea Medical Science Institute)
Kim, Hee-Seok (Korea Medical Science Institute)
Kim, Byoung-Chul (Korea Medical Science Institute)
Hwang, Sung-Wan (Korea Medical Science Institute)
Hwang, Sung-Yeoun (Korea Medical Science Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.3, 2007 , pp. 305-310 More about this Journal
Abstract
This study was designed to investigate the effects of KH-305 on erectile dysfunction in young rats, via nitric oxide (NO)-cGMP pathways. After oral administration of the KH-305 mixture (50, 100, 200, 300 mg/kg) to young rats for 10 days, NOS and SOD protein expressions in penile tissue and testosterone in plasma were measured. cGMP degradation was also investigated using bovine vascular smooth muscle cells pretreated with an NO donor, S-nitroso-N-Acetylpenicillamine (SNAP). The penile expression levels of nNOS and eNOS-dependent NOS activities as well as SOD preventing oxidative stress by overproduction of NO were increased significantly. Also, the concentration of testosterone in the plasma was increased. In vitro, cGMP concen-trations were decreased dose dependently in the KH-305. These results suggest that KH-305 may be useful in erectile dysfunction.
Keywords
erectile dysfunction; NOS; cGMP; testosterone;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 1
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