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http://dx.doi.org/10.3746/jkfn.2007.36.3.276

Anti-atherogenic Effect of Isoflavone through Hypolipidemic, Anti-oxidative and Anti-inflammatory Actions in C57BL/6 Mice  

Cho, Hye-Yeon (Paik Inje Memorial Clinical Research Institiute, School of Medicine, Inje University)
Yang, Jeong-Lye (Busan Newport Import Food Inspection Office, Busan Regional Food & Drug Administration)
Noh, Kyung-Hee (School of Food and Life Sciences, Food Science Institute, and Biohealth Product Research Center, Inje University)
Kim, Jin-Ju (School of Food and Life Sciences, Food Science Institute, and Biohealth Product Research Center, Inje University)
Kim, Young-Hwa (School of Food and Life Sciences, Food Science Institute, and Biohealth Product Research Center, Inje University)
Huh, Kyung-Hye (Major in Molecular & Biomedical Technology, Inje University)
Song, Young-Sun (School of Food and Life Sciences, Food Science Institute, and Biohealth Product Research Center, Inje University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.3, 2007 , pp. 276-283 More about this Journal
Abstract
This study was carried out to investigate the effect of isoflavone on the atherogenic effect in C57BL/6 mice. C57BL/6 female mice, 5 weeks of age, were fed on chow diets for 2 weeks during adjustment period. Mice weighing approximately $17.9{\pm}0.9\;g$ were divided into 4 groups and were fed on the experimental diets containing isoflavone for 8 weeks. Experimental groups were control (atherogenic diet), IF-10 (atherogenic diet with isoflavone 10 mg/100 g diet), IF-40 (atherogenic diet with isoflavone 40 mg/100 g diet) and IF-100 (atherogenic diet with isoflavone 100 mg/100 g diet). Food efficiency ratio was not different among the experimental groups. Plasma triglyceride (TG) concentrations were lower after 4 weeks in isoflavone supplementation groups than in control group, whereas monocyte chemoattractant protein-1 and thiobarbituric acid reactive substances (TBARS) levels of plasma were significantly (p<0.05) decreased in the isoflavone supplementation groups in a dose dependent manner. Both hepatic TG and cholesterol levels were significantly lowered in IF-100 than control. Hepatic glutathione concentrations were higher in the IF-100 group than in the other groups. Hepatic antioxidant enzyme activities including glutathione-reductase, glutathione-peroxidase, catalase, and Mn-superoxide dismutase were significantly higher in the isoflavone supplemen-tation groups in a dose dependent manner. From the above results, it is concluded that isoflavone may reduce the risk of atherosclerosis via hypolipidemic, anti-oxidative and anti-inflammatory effects.
Keywords
anti-oxidative and anti-inflammatory effect; antioxidant enzyme activity; atherosclerosis; isoflavone; lipid level; monocyte chemoattractant protein-1;
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Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By SCOPUS : 1
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