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http://dx.doi.org/10.3746/jkfn.2007.36.3.269

Effect of Asterina pectinifera Extracts on the Activation of Immune Cells  

Chae, Su-Yeon (Dept. of Biology, College of Natural Science, Sunchon National University)
Kim, Mi-Jung (Dept. of Biology, College of Natural Science, Sunchon National University)
Kim, Do-Soon (Dept. of Biology, College of Natural Science, Sunchon National University)
Park, Jung-Eun (Dept. of Biology, College of Natural Science, Sunchon National University)
Jo, Sung-Kee (Radiation Food and Biotechnology Team, Advanced Radiation Technology Institute, Jeongup Campus of Korea Atomic Energy Research Institute)
Yee, Sung-Tae (Dept. of Biology, College of Natural Science, Sunchon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.3, 2007 , pp. 269-275 More about this Journal
Abstract
In this experiment, the effects of Asterina pectinifera extracts on the activation of immune cells were studied. An immune cell activating factor was partially purified from starfish, Asterina pectinifera, by means of physiological saline extraction, acetone precipitation and heating inactivation. Starfish extracts increased the proliferation of spleen cells and induced the production of IL-6 and $IFN-{\gamma}$ by spleen cells. Also, it increased the proliferation of purified B cells and production of IgM and IgG in the presence of Asterina pectinifera extracts. Starfish extract self-induced NO synthesis in mouse macrophage cell line (RAW264.7). When cell lines was treated with extracts, the mRNA expression of inducible NO synthetase (iNOS), $TNF-{\alpha}$, IL-6, and GM-CSF were markedly increased in RT-PCR analysis. Therefore starfish extract can self-activate spleen cells, B cells and macrophages. These results might be useful in further studies into a possible immune activating agent from the starfish, Asterina pectinifera, for the development of functional foods and drugs.
Keywords
Asterina pectinifera; B cell; cytokines; immunoglobulins; nitric oxide;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 1
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