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http://dx.doi.org/10.3746/jkfn.2007.36.2.180

Cholesterol Contents of Pork Fed Dietary β-Cyclodextrin  

Kang, Hwan-Ku (Dept. of Animal Biotechnology, Kangwon National University)
Park, Byung-Sung (Dept. of Animal Biotechnology, Kangwon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.2, 2007 , pp. 180-185 More about this Journal
Abstract
This study demonstrates that pork cholesterol levels are reduced in fattening stage swine fed $\beta-cyclodextrin({\beta}-cyclodextrin)$. The study subjects were 120 swine fed their respective chow diets containing 0, 5, 7, or 10% $\beta$-cyclodextrin for 35 consecutive days. Plasma total lipids, triglyceride and total cholesterol of the $\beta$-cyclodextrin treated group were significantly lower than those of the control group (p<0.05). The levels of plasma lipid were significantly decreased by 63.22 mg, 73.98 mg, and 82.12 mg in the fattening swine group fed $\beta$-cyclodextrin at 5%, 7%, and 10%, respectively, compared to those in the control group (p<0.05). When 5, 7, and 10% $\beta$-cyclodextrin was administered to fattening swine, the triacylglyceride levels were decreased by 56.24 mg, 55.48 mg, and 60.02 mg, and total cholesterol concentration was reduced by 25.05 mg, 27.17 mg, and 30.19 mg, respectively, compared to those in the control group (p<0.05). Excretion of total steroid significantly (p<0.05) increased with the increasing amount of $\beta$-cyclodextrin supplementation. The cholesterol levels of swine back fat, belly, loin, and ham were significantly decreased with increasing $\beta$-cyclodextrin supplementation (p<0.05). The pork cholesterol was significantly (p<0.05) reduced by 15.31% in the $\beta$-cyclodextrin treated group, compared to that of the control group. These results suggest that feeding $\beta$-cyclodextrin to fattening swine may produce novel functional pork with low cholesterol levels.
Keywords
swine; $\beta-cyclodextrin$; plasma lipid; bile acids; pork cholesterol;
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1 Grundy SM. 1983. Absorption and metabolism of dietary cholesterol. Ann Rev Nutr 3: 71-96   DOI   ScienceOn
2 Saenger W. 1984. Structural aspects of cyclodextrins and their inclusion complexes. Incl Compounds 2: 231-243
3 Rao R, Kumar SU, Rao DN, Divakar S. 2000. Optimization of digestion parameter for the elemination of residual $\beta$- cyclodextrin used for cholesterol reduction in egg using glucoamylase. Eur Food Res Technol 210: 231-236   DOI
4 Riottot M, Olivier P, Lutton C. 1993. Hypolipidemic effects of $\beta$-cyclodextrin in the hamster and in the genetically hypercholesterolemic rico-rat. Lipids 28: 181-188   DOI
5 Juste C, Catala I, Riottot M, Andre M, Parquet M, Lyun B, Bequet F, Ferezou-viala J, Serougne C, Domingo N, Lutton C, Lafont H, Corring T. 1997. Inducing cholesterol precipatation from pig bile with $\beta$-cyclodextrin and cholesterol dietary supplementation. J Hepatology 26: 711-721   DOI   ScienceOn
6 Okenfull DG, Pearce RI, Sidhu GS. 1991. Low-cholesterol dairy product. Aust J Dairy Techol 46: 110-112
7 Ulbrecht F, Reich H. 1992. Gas chromatographic determination of cholesterol in processed foods. Food Chem 43: 387-391   DOI   ScienceOn
8 Grundy SM, Ahrens Jr EH, Miettinen TA. 1965. Quantitative isolation and gas-liquid chromatographic analysis of total fecal bile acids. J Lipid Res 6: 397-410
9 Leaf A, Weber PC. 1988. Cardiovascular effect of n-3 fatty acid. New Engl J Med 318: 549-553   DOI   ScienceOn
10 Smith DM, Awad AC, Bennick MR, Gill JL. 1995. Cholesterol reduction in liquid egg using $\beta$-cyclodextrin. J Food Sci 60: 691-694   DOI   ScienceOn
11 Yen GC, Chen CJ. 2000. Effects of fractionation and the refining process of lard on cholesterol removal by $\beta$- cyclodextrin. J Food Sci 65: 622-624   DOI   ScienceOn
12 USDA. 2000. USDA Nutrient database for standard references. Release 13. U.S. Department of agriculture, Agriculture research service, Beltsville, MD
13 Park BS, Kang HG, Jang A. 2005. Influence of feeding $\beta$- cyclodextrin to laying hens on the egg production and cholesterol content of yolk. Asian Aust J Anim Sci 18: 835-840   DOI
14 Park BS. 2004. Effect of dietary $\beta$-cyclodextrin on egg quality and cholesterol content of egg yolks. J Korean Soc Food Sci Nutr 33: 614-620   과학기술학회마을   DOI   ScienceOn
15 Grundy SM. 1986. Cholesterol and coronary heart disease. JAMA 256: 2849-2858   DOI
16 Horikoshi K. 1979. Production and industrial applications of beta-cyclodextrin. Process Biochem 14: 26-30
17 Dorado M, Martin GEM, Jimenez-Colmenero F, Masoud TA. 1999. Cholesterol and fat contents of spanish commercial pork cuts. Meat Sci 51: 321-323   DOI   ScienceOn
18 Bragagnolo N, Rodriguez DB. 2002. Simultaneous determination of total lipid, cholesterol and fatty acids in meat and back fat of suckling and adult pigs. Food Chem 79: 255-260   DOI   ScienceOn
19 Piironen V, Toivo J, Lampi AM. 2002. New data for cholesterol contents in meat, fish, milk, eggs and their products cinsumed in finland. J Food Comp Anal 15: 705-713   DOI   ScienceOn
20 Nagatomo S. 1985. Cyclodextrins-expanding the development of their functions and applications. Chemical Economy and Engineering Review 17: 28-34
21 News week. 1992. Betting on a guilt-free egg. Newsweek April 6: 46
22 Frijlink HW, Eissens AC, Hefting NR, Poelstra K, Lerk CF, Meijer DKF. 1991. The effects of parenterally administered cyclodextrin on cholesterol levels in the rat. Pharm Res 8: 9-16   DOI
23 Suzuki M, Sato A. 1985. Nutritional significance of cyclodextrins: indigestibility and hypolipidemic effects of $\beta$- cyclodextrin. J Nutr Sci Vitaminol 31: 209-223   DOI
24 Ferezou J, Riottot M, Serougne C, Cohen-solal C, Catala I, Alguier C, Parguet M, Juste C, Lafont H, Mathe D, Corring T, Lutton C. 1997. Hypocholesterolemic action of $\beta$-cyclodextrin and its effects on cholesterol metabolism in pigs fed a cholesterol-enrich diet. J Lipid Res 38: 86-100
25 Oliver P, Verwaerde F, Hedges AR. 1991. Subchronic toxicity of orally administered beta-cyclodextrin in rats. J Am Coll Toxicol 10: 407-419   DOI
26 Favier ML, Remesy C, Moundras C, Demigne C. 1995. Effect of cyclodextrin on plasma lipids and cholesterol metabolism in the rat. Metabolism 44: 200-206   DOI   ScienceOn
27 Park BS. 2003. The biological effect of $\beta$-cyclodextrin on antithrombotic activity and plasma lipid metabolism in rats. J Anim Sci (Kor) 45: 199-210
28 Park BS. 2006. Influence of feeding $\beta$-cyclodextrin on reducing the content of cholesterol in pork. J Korean Soc Food Sci Nutr 35: 328-334   과학기술학회마을   DOI   ScienceOn
29 National Research Council. 1998. Nutrient requirements of swine. 10th edition. National Academy Press, Washington DC, USA
30 Folch L, Lees M, Sloane-Stanley SHA. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-507
31 Miettinen TA, Ahrens Jr EH, Grundy SM. 1965. Quantitative isolation and gas liquid chromatographic analysis of total dietary and fecal neutral steroids. J Lipid Res 6: 411-424
32 Abadie C, Hug M, Kubli C, Gains N. 1994. Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces. Biochem J 299: 725-730   DOI
33 SAS Institute. 2000. $SAS^{\circledR}$ User's guide: Statistics. Version 8 edition. SAS Institute Inc., Cary, NC, USA.33
34 Duncan DB. 1955. Multiple range and multiple F-test. Biometrics 11: 1-6   DOI   ScienceOn
35 Froming KH, Fridrich R, Mehnert W. 1993. Inclusion compounds of cholesterol and $\beta$-cyclodextrin. Eur J Pharm Biopharm 39: 148-152
36 Flourie B, Molis C, Achour L, Dupas H, Hatat C, Rambaud JC. 1993. Fate of $\beta$-cyclodextrin in the human intestine. J Nutr 123: 676-680   DOI