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http://dx.doi.org/10.3746/jkfn.2007.36.2.155

Inhibitory Effects of Phyto Extract Mixture (PEM381) on Type I Allergic Reaction  

Kim, Kyung-Bum (Technology Research Center, Ben's Lab Co., Ltd.)
Lee, Eu-Gene (Technology Research Center, Ben's Lab Co., Ltd.)
Chai, Ok-Hee (Dept. of Anatomy, Chonbuk National University Medical School)
Song, Chang-Ho (Dept. of Anatomy, Chonbuk National University Medical School)
Jeong, Jong-Moon (Dept. of Life Science, The University of Suwon)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.2, 2007 , pp. 155-162 More about this Journal
Abstract
The purpose of this study is to investigate the anti type I allergic effects and mechanisms of the phyto extract mixture (PEM381) which contains Camellia sinensis (leaf), Psidium guajava (leaf), and Rosa hybrida (flower). PEM381 was tested for its inhibitory effects on arachidonic acid cascade related enzymes (5-lipoxygenase and cyclooxygenase), the mast cell mediated allergic reaction and passive cutaneous anaphylaxis. $IC_{50}$ value of PEM381 against 5-lipoxygenase was $14.11{\pm}0.51ppm$ while that of positive control (nordihy-droguaiaretic acid) was $0.54{\pm}0.08ppm$. PEM381 also exhibited considerable selective inhibition of cyclooxygenase-2. PEM381 could inhibit both degranulation and histamine release in a dose dependent manner from rat peritoneal mast cells activated by compound 48/80. In addition, oral administration of PEM381 showed an inhibitory effect on passive cutaneous anaphylaxis reaction activated by anti-dinitrophenyl IgE antibody in mice. These results suggest that PEM381 may be useful for the prevention and treatment of type Ⅰ allergy related diseases.
Keywords
PEM381; 5-lipoxygenase; cyclooxygenase; mast cell; histamine;
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Times Cited By SCOPUS : 4
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