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http://dx.doi.org/10.3746/jkfn.2007.36.11.1377

Effects of Phyto-Extract Mixture (PEM381) in Type I Allergic Reaction-Induced Mice  

Kim, Kyung-Bum (Technology Research Center, Ben's Lab Co., Ltd.)
Park, Jeong-Su (Department of Life Science, The University of Suwon)
Jeong, Jong-Moon (Department of Life Science, The University of Suwon)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.11, 2007 , pp. 1377-1384 More about this Journal
Abstract
A previous study suggested that the phyto-extract mixture (PEM381) containing Camellia sinensis (leaf), Psidium guajava (leaf), and Rosa hybrida (flower) inhibited not only arachidonic acid cascade-related enzymes (5-lipoxygenase and cyclooxygenase) in vitro but also degranulation and histamine release from rat peritoneal mast cells. In this study, the same PEM381 was used to investigate its inhibitory effects on the syntheses of leukotrienes and prostaglandins as well as on serum concentration of histamine and eosinophils infiltration in type I allergic reaction-induced mice. The PEM381 could decrease concentrations of serum cysteinyl leukotrienes from mice activated by anti-DNP IgE and DNP-albumin. The concentration of serum histamine by oral administration of PEM381 (25, 50, and 100 mg/kg of body weight) in type I allergic reaction-induced mice was $395.93{\pm}190.37$ nM, $315.59{\pm}164.23$ nM, and $325.07{\pm}112.02$ nM, respectively, while that of positive control (promethazine hydrochloride 10 mg/kg of body weight) was $270.12{\pm}24.02$ nM. In addition, the PEM381 also showed inhibitory effect on the eosinophils infiltration in the nasal mucosa of mice which were sensitized with ovalbumin. However, the effect of PEM381 on the syntheses of prostaglandins seemed to be insignificant. Consequently, these results suggest that PEM381 may be useful for the prevention and treatment of type I allergy-related diseases.
Keywords
PEM381; prostaglandins; leukotrienes; histamine; eosinophils;
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