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http://dx.doi.org/10.3746/jkfn.2007.36.11.1365

Effect of Methanol Extracts of Red Colored Rices on Antioxidant Activity and Growth Inhibitory Activities of Cancer Cells  

Park, Sung-Hee (Food Function Research Group, Korea Food Research Institute)
Cho, Il-Jin (Food Function Research Group, Korea Food Research Institute)
Kim, Yong-Sik (School of Nutrition and Hotel Culinary Art, Anyang Technical College)
Ha, Tae-Youl (Food Function Research Group, Korea Food Research Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.11, 2007 , pp. 1365-1370 More about this Journal
Abstract
The inhibitory effects of the water and methanol extracts of Jakwangdo and Honghyangmi on the rat microsome lipid peroxidation and growth of four human cancer cells such as HepG2 (liver cancer), SNU-1 (stomach cancer) MCF-7 (breast cancer) and SNU-C4 (colon cancer) were examined. The methanol extracts of red colored rices showed the antioxidant activity and growth inhibitory effects of cancer cells. However, water extracts did not show the activities. Inhibitory activities of methanol extracts of Jakwangdo and Honghyangmi against lipid peroxidation of rat microsome was 80% and 68%, respectively, at the concentration of 1 mg/assay. Jakwangdo methanol extracts showed the highest growth inhibitory activity in MCF-7 cells among the cancer cells tested. The methanol extracts of red colored rices were further fractionated with hexane, chloroform, ethyl acetate and butanol. Both chloroform and hexane fractions showed strong growth inhibitory activity in HepG2 and MCF-7 cells.
Keywords
red colored rice; lipid peroxidation; cytotoxicity; cancer cells;
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Times Cited By KSCI : 12  (Citation Analysis)
Times Cited By SCOPUS : 1
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