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http://dx.doi.org/10.3746/jkfn.2006.35.7.823

Cytotoxic Effect of Extracts from Styela clava against Human Cancer Cell Lines  

Jung, Eun-Sil (Dept. of Food Science and Biotechnology, Kyungnam University)
Kim, Ju-Young (Dept. of Food Science and Biotechnology, Kyungnam University)
Park, Eun-Ju (Dept. of Food and Nutritional Sciences, Kyungnam University)
Park, Hae-Ryong (Dept. of Food Science and Biotechnology, Kyungnam University)
Lee, Seung-Cheol (Dept. of Food Science and Biotechnology, Kyungnam University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.35, no.7, 2006 , pp. 823-827 More about this Journal
Abstract
The present study describes the preliminary evaluation of the cytotoxic effect from Styela clava (Korean name : miduduk) extracts. S. clava was treated with methanol, ethanol, acetone, and water, then cytotoxic effect of the extracts were evaluated by the MTT reduction assay. The ethanol extracts from S. clava showed the cytotoxic activity on the HT-29 human colon cancer cells. The ethanol extracts was further fractionated with n-hexane, diethyl ether, ethyl acetate, and water according to the degree of polarity. The diethyl ether fraction showed high cytotoxic activity of HT-29 cells. however, the other fractions showed low cytotoxicity. The diethyl ether layer also showed the cytotoxic activity against SW620, HeLa, and MCF-7 cells. These studies support that extracts from S. clava may be a potential candidate as a possible chemotherapeutic agent against human cancer cells.
Keywords
Styela clava; cytotoxic effect; MTT reduction assay; human cancer cell lines;
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Times Cited By KSCI : 1  (Citation Analysis)
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