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http://dx.doi.org/10.3746/jkfn.2005.34.9.1344

Protective Effects of Welsh Onion (Allium fistulosum L.) on Drug-induced Hepatotoxicity in Rats  

Cha, Hwan-Soo (Korea Food Research Institute)
Seong, Ki-Seung (Korea Food Research Institute)
Kim, Sung-Ho (Jindo Agricultural Technology Center)
Seo, Ji-Woo (Jindo Agricultural Technology Center)
Park, Sun-Joo (Korea Food Research Institute)
Kim, Soon-Im (Korea Food Research Institute)
Lee, Kyung-Won (Korea Food Research Institute)
Yoon, So-Rah (College of Veterinary Medicine, Seoul National University)
Han, Dong-Un (Chonan Yonam College)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.9, 2005 , pp. 1344-1349 More about this Journal
Abstract
The aim of this study was to evaluate the effects of Welsh onion administration on $CCl_4$-induced hepatic injury in rats. The increasing rate of the body and organ weight was not significantly different by the ad-ministration of the Welsh onion. Welsh onion (2, 4, $10\%$ w/w) was given for 4 weeks with the injections of $CCl_4$. Total serum lipid was significantly decreased in all treatment groups compared to $CCl_4$ only treatment group (p<0.05). The Welsh onion from winter season was more protective effect by lowering the serum levels of transminase (SGOT and SGPT) compared with others, the levels of transminase - phosphatase (ALP) in serum. The Welsh onion from winter at a dose of $4\%,\;10\%$ (w/w) showed significantly hepatoprotective activity which was comparable to that $CCl_4$-induced hepatic damage. Histological evaluation showed that Welsh onion partially prevented $CCl_4$-induced inflammation, necrosis and vacuolation. Pretreatment of Welsh onion reduced extent of the necrosis found 24 hr after the intraperitoneal administration of $CCl_4$. The present study shows the liver protective action of the Welsh onion against experimentally induced liver damage in rats. This suggests that the Welsh onion may be used as an effective hepatoprotective agent.
Keywords
Welsh onion; alkaline phosphatase; total lipid; carbon tetrachloride; hepatoprotective;
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