Browse > Article
http://dx.doi.org/10.3746/jkfn.2005.34.9.1308

Antioxidative and Antihypertensive Effects of Lycii fructus Extracts  

Cho, Young-Je (Dept. of Food Engineering, Sangju Notional University)
Chun, Sung-Sook (Dept. of Food Science ar Technology, Yeungnam University)
Cha, Weon-Seup (Dept. of Food Engineering, Sangju Notional University)
Park, Joon-Hee (Dept. of Food Engineering, Sangju Notional University)
Lee, Kyoung-Hwan (Dept. of Food Engineering, Sangju Notional University)
Kim, Jeung-Hoan (Dept. of Food Engineering, Sangju Notional University)
Kwon, Hyo-Jung (Dept. of Food Engineering, Sangju Notional University)
Yoon, So-Jung (Dept. of Food Engineering, Sangju Notional University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.9, 2005 , pp. 1308-1313 More about this Journal
Abstract
The physiological activity of Lycii fructus extracts were examined. Total phenolic contents in the ethanol extracts (9.5 mg/g) of Lycii fructus were higher than that of water extracts (8.7 mg/g). The chlorogenic acid ($1.7{\mu}g$ in water extracts and $1.3{\mu}g$ in $60\%$ ethanol extract) was the most abundant phenolic compound as analyzed by HPLC. The ABTS [2,2'-azinobis (3-othylbenfothiaznoline-6- sulfornic acid)] radical decolor-ization electron donating ability (DPPH) and antioxidant protection factor (PF) were determined for extracts from Lycii fructus. Water extract ($76.7\%$ on ABTS, $92.6\%$ on DPPH and 1.1 on PF) showed higher inhibition rate than $60\%$ ethanol extracts ($52.8\%,\;88.8\%$ and 1.0). Thiobarbituric acid reactive substance (TBARS) was determined as $1.5{\times}10^{-3}\;{\mu}M$ in $60\%$ ethanol extract. Ethanol extracts was more effective in decreasing TBARS than water extracts. The water extracts from Lycii fructus had higher angiotensin converting enzyme (ACE) inhibition activity than ethanol extracts. The result will be useful for functional foods application and under-standing the physiological activities of Lycii fructus.
Keywords
Lycii fructus; physiological activity; angiotensin converting enzyme; antioxidant;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Park YJ, Kim MH, Bae SJ. 2002. Enhancement of anticarcinogenic effect by combination of Lycii fructus with vitamin C. J Korean Soc Food Sci Nutr 31: 143-148   DOI   ScienceOn
2 Park JS, Park JD, Lee BC, Choi KJ. 2000. Effects of extracts from various parts of Lycium chinense Mill. on proliferation of mouse spleen cells. Korean J Medicinal Crop Sci 8: 291-296
3 Do JR, Kim SB, Park YH, Kim DS. 1993 Angiotensin-I converting enzyme inhibitiory activity by the component of traditional tae material. Korean J Food Sci Technol 25: 456-460
4 Shin JS, Kim KS, Jeong GH, Cheong CS. 1997. Antidiabetic activity of Lycii fructus. Kor J Pharmacogn 28: 138-142
5 Kim KS, Shim SH, Jeong GH, Cheong CS. 1998. Antidiabetic activity of constituents of Lycii fructus. J Applied Pharmacology 6: 378-382
6 Kim HK, Kim YE, Do JR, Lee YC, Lee BY. 1995. Antioxidative activity and physiological activity of some Korean medicinal plants. Korean J Food Sci Technol 27: 80-85
7 Kim HS, Park YS, Kim CI. 1998. Changes of serum lipid profiles after eating Lycii fructus in rats fed high fat diet. Korean J Nutr 31: 263-270
8 Lee MY, Sheo HJ. 1986. Quantitive analysis of total amino acids and free sugars in Lycii fructus. J Korean Soc Food Nutr 15: 249-252
9 Miquel J, Quintaniha AT, Weber H. 1090. Handbook of free radical and antioxidants in biomedicine. CRC Press, Boca Raton, USA. Vol I, p 223
10 Aruoma OI. 1998. Free radical, oxidative stress and antioxidants in human health and diwease. J Am Oil Chem Soc 75: 199-212   DOI   ScienceOn
11 Douglas WW. 1980. The Plasmacological basis of thera peutics. 6th ed. Gilman AG, Goodman LS, Gilman A, eds. McMillian Publishing Co, Inc., New York, USA. Chapter 27
12 Cushman DW, Ondetti MA. 1980. Inhibition of angiotensin-converting enzyme for treatment of hypertensin. Biochem Pharmacol 29: 1871 -1876   DOI   ScienceOn
13 Stewart JM, Ferreira SH, Greene LJ, 1971. Bradykinin potentiating peptide PCA-Lys-Trp-Ala-Pro. An inhibitior of the pulmonary inactivation of bradykinin and conversion of angiotensin I to II. Biochem Pharmacol 20: 1557-1567   DOI   ScienceOn
14 Gavras H, Brunner HR, Laragh JH, Sealey JE, Gravras I, Vukovich RA. 1974. An angiotensin converting-enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patients. N Engl J Med 291: 817-821   DOI   ScienceOn
15 Case DB, Wallace JM, Keim HJ, Weber MA, Drayer JI, White RP, Sealey JE, Laragh JH. 1976. Estimating renin participation in hypertension: superiority of converting enzyme inhibitior over saralasin. Am J Med 61: 790-796   DOI   ScienceOn
16 Pertrillo EW, Ondetti MA. 1982 Angiotensin converting enzyme inhibitors: Medicinal chemistry and biological actions. Med Chem Biol Act Med Res 2: 1-5
17 Wyvratt MJ, Patchett AA. 1985. Recent developments in the design of angiotensin-converting enzyme inhibitors. Med Res Rev 5: 483-488   DOI   ScienceOn
18 Kim HK, Kim YE, Do JR, Lee YC, Lee BY. 1995. Antioxidantive activity and physiological activity of some Korean medicinal plants. Korean J Food Sci Technol 27: 80-85
19 Soffer RL. 1976 Angiotensin-converting enzyme and the regulation of vasoactive peptides. Ann Rev Biochem 45: 73-77   DOI   ScienceOn
20 Ondetti MA, Cushman DW. 1982 Enzymes of the renin-angiotensin system and their inhibitiors. Ann Rev Biochem 51: 283-291   DOI   ScienceOn
21 Pellegrin N, Roberta R, Min Y, Catherine RE. 1998. Screening of dietary carotenoids and carotenoid-rich fruit extracts for antioxidant activites applying 2,2' -azinobis(3-ehylenebenzothiazoline-6-sulfonic acid) radical cation decolorization assay. Method Enzymol 299: 379-389
22 Lee BC, Park JS, Kwak TS, Moon CS. 1998. Variation of chemical properties in collected boxthom varieties. Korean J Breed 30: 267-272
23 Science, the encyclopedia publishing company it compiles. 1999. Ingredient and use of medical plant. From January angle, Seoul
24 Dural B, Shetty K. 2001. The stimulation of phenolics and antioxidant activity in pea (Pisum sativum) elicited by genetically transformed anise root extract. J Food Biochem 25: 361-377   DOI   ScienceOn
25 Gebhardt R. 1998. Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke (Cynara scolymus L.) extract. J Phamacol Exp Ther 286: 1122-1128
26 Tsuchiya T, Suzuki O, Igarashi K. 1996. Protective effects of chlorogenic acid on paraquat-induced oxidative stress in rats. Biosci Biotechnol Biochem 60: 765-768   DOI   ScienceOn
27 Hollenberg NK. 1979. Pharmacologic interruption of the renin-angiotensin system. Ann Rev Pharmacol Toxicol 19: 559-565   DOI   ScienceOn
28 Blois MS. 1958. Antioxidant determination by the use of stable free radical. Nature 26: 1198-1199
29 Andarwulan N, Shetty K. 1999. Phenolic content in differentiated tissue cultures of untransformed and Agrobacterium-transformed roots of anise (Pimpinella anisum L.) J Agric Food Chem 47: 1776-1780   DOI   ScienceOn
30 Buege JA, Aust SD. 1978. Microsomal lipid peroxidation. Method Enzymol 105: 302-310
31 Cushman DW, Ondetti MA. 1980. Inhibitors of angiotensin converting enzyme for treatment of hypertension. Biochem Pharmacol 29: 1871-1877   DOI   ScienceOn
32 Cuvelier ME, Richahard H, Berset C. 1998. Antioxidative activity of phenolic composition of pilot plant and comercial extracts of sage and rosemary. J Am Oil Chem Soc 73: 645-652   DOI   ScienceOn
33 Cha JY, Cho YS. 1999. Effect of potato polyphenolics on lipid peroxidation in rats. J Korean Soc Food Sci Nutr 28: 1131-1136
34 Fridovich I. 1986. Biological effects of the superoxide radical. Arch Biochem Biophys 247: 1-15   DOI   ScienceOn
35 Kono Y, Kashone S, Yoneyama T, Sakamoto Y, Matsu Y, Shibata H. 1998. Iron chelation by chlorogenic acid as a natural antioxidant. Biosci Biotechnol Biochem 62: 22-27   DOI   ScienceOn
36 Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. 1993. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011   DOI   ScienceOn
37 Kim HK, Kim YE, Do JR, Lee YC, Lee BY. 1995. Antioxidative activity and physiological activity of some Korean medical plants. Korean J Food Sci Technol 27: 80-85
38 Noh H, Song KB. 2001. Isolation of an angiotensin converting enzyme inhibitor from Oenathe javanica. Agric Chem Biotechnol 44: 98-99
39 Oh SJ, Kim SH, Kim SK, Baek YJ, Cho KH. 1997. Angiotensin I-converting enzyme inhibitory activity of the K-casein fragments hydrolyzated by chymosin, pepsin, and trysin. Fractionation of angiotensin converting enzyme (ACE) inhibitory peptides from soybean paste. Korean J Food Sci Technol 27: 230-234
40 Funayama S, Hikono H. 1979. Hypotensive principles of Diospyros kaki leaves. Chem Pharm Bull 27: 2865-2869   DOI   ScienceOn
41 Brieskorm CH, Fuch A, Bredenberg JB, McChensney JD, Wenkert E. 1964. The structure of carnosol. J Org Chem 29: 2293-2297   DOI