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http://dx.doi.org/10.3746/jkfn.2005.34.6.825

Effects of Fomes fomentarius Extract on Blood Glucose, Lipid Profile and Immune Cell in Streptozotocin-Induced Diabetic Rats  

Kim, Na-Young (Dept. of Food and Nutrition, Dong-A University)
Jung, Ho-Kum (Dept. of Food and Nutrition, Dong-A University)
Park, Myoung-Ju (Dept. of Food and Nutrition, Dong-A University)
Kim, Seog-Ji (Dept. of Food and Nutrition, Dong-A University)
Kim, Seok-Hwan (Dept. of Food and Nutrition, Dong-A University)
Choi, Jong-Won (Dept. of Pharmacy, Kyungsung University)
Lee, Jeong-Sook (.Dept. of Food and Nutrition, Kosin University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.6, 2005 , pp. 825-832 More about this Journal
Abstract
This study was conducted to investigate the effect of extract of Fomes fomentarius (FF) on blood glucose, lipid profile, antioxidant enzymes and immune cells in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into control, STZ-induced diabetic group (DM), STZ plus FF water extract treated group (DM-FW 200) and STZ plus FF methanol extract treated group (DM-FM 200). FW (200 mg/kg BW) and FM (200 mg/kg BW) were orally administered once a day for 14 days. Admdinistering FW and FM to STZ-induced diabetic rats lowered the blood glucose level. The supplementation of FW and FM suppressed the increase in the total cholesterol and triglyceride levels in the serum and liver of the diabetic rats. The high density lipoprotein-cholesterol level and glutathione peroxidase activity were higher in the FF-sup-plemented group compared to the diabetic group. Administering FW and FM increased the suppress in the serum complement component C3, whole blood B-cell, T-cell, helper T cell and suppressor T cell of the diabetic rats. Therefore, it could be suggested that FW and FM are alleviated the diabetic complication through enhancing the hyperglycemia and preventing diabetic complications.
Keywords
Fomes fomentarius; diabetes; lipid profile; immune cell;
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