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http://dx.doi.org/10.3746/jkfn.2005.34.6.771

Growth Inhibition Effects of Cancer Cell Lines by Gloiopeltis furcata Fractions in Vitro  

Park, Soung-Young (Dept. of Food and Nutrition, Marine Biotechnology Center for Biofunctional Material Industries, Silla University)
Jung, Bok-Mi (Dept. of Food Science and Nutrition, Yosu National University)
Choi, Yung-Hyun (Dept. of Biochemistry, College of Oriental Medicine and Research Institute of Orental Medicine, Dong-Eui University)
Bae, Song-Ja (Dept. of Food and Nutrition, Marine Biotechnology Center for Biofunctional Material Industries, Silla University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.6, 2005 , pp. 771-775 More about this Journal
Abstract
The growth inhibitory effects on human cancer cell lines provide useful information regarding critical cellular targets. Reports on cytotoxicity of Gloiopeltis furcata (GF) to human cancer cell lines are conflicting. This study was performed to investigate the effects of cytotoxicity and quinone reductase activity of Gloiopeltis furcata on the human cancer cells. The four partition layers of methanol extracts (GFM) which are hexane (GFMH), methanol (GFMM), butanol (GFMB) and aquous (GFMA) were screened for their cytotoxic effects on HepG2, HeLa, MCF-7, HT-29, and normal liver cell lines. The GFMM showed the strongest growth inhibition effect on all cell lines we used. the GFMM showed the highest induction activity of quinone reductase on HepG2 cells among the other partition layers.
Keywords
cytotoxicity; quinone reductase; Gloiopeltis furcata;
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Times Cited By KSCI : 5  (Citation Analysis)
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