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http://dx.doi.org/10.3746/jkfn.2005.34.5.738

Effects of Acorn (Quercus acutissima CARR.) Supplementation on the Level of Acetylcholine and Its Related Enzyme Activities in the Brain of Dementia Mouse Model  

Lee, Sung-Hyeon (National Rural Resources Development Institute, NIAST, RDA)
Kim, Dae-Ik (National Rural Resources Development Institute, NIAST, RDA)
Cho, So-Yong (National Rural Resources Development Institute, NIAST, RDA)
Jung, Hyun-Jin (National Rural Resources Development Institute, NIAST, RDA)
Cho, Soo-Muk (National Rural Resources Development Institute, NIAST, RDA)
Park, Hong-Ju (National Rural Resources Development Institute, NIAST, RDA)
Lillehoj Hyun S. (Animal and Natural Resources institute, ARS- USDA)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.5, 2005 , pp. 738-742 More about this Journal
Abstract
This study was designed to investigate the anti-dementia effects of acorn (Quercus acutissima CARR.) in brain of the mouse. Dementia model was induced by administration of scopolamin (30 mg/kg BW) Male ICR mouse $(30{\pm}2g\;BW)$ were fed basal diet (control group), and experimental diets (AP-5 and AP-10 groups) added $5\%\;and\;10\%$ of dried acorn powder to basal diet for 8 months. Acetylcholine content significantly increase in AP-5 and AP-10 groups ($4.2\%\;and\;11.3\%$, respectively) compared with control group. Acetylcholinesterase activities were significantly inhibited ($13.5\%\;and\;17.6\%$, respectively) in brain of AP-5 and AP-10 groups. Monoamine oxidase-B (MAO-B) activities were significantly inhibited ($10.0\%\;and\;12.7\%$, respectively) in brain of AP-S and AP-10 groups. These results suggest that acorn (Q. acutissima CARR.) may play an effective role in an attenuating various age-related changes such as dementia including learning and memory impairments in brain.
Keywords
acorn; dementia; acetylcholine; acetylcholineterase; monoamine oxidase-B;
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