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http://dx.doi.org/10.3746/jkfn.2005.34.5.632

Effect of Hovenia dulcis Thunb Extract on the Hyperglycemic Mice Induced with Streptozotocin  

Kim, Jeong-Sang (College of Oriental Medicine, Dongshin University)
Na, Chang-Soo (College of Oriental Medicine, Dongshin University)
Eun, Jong-Bang (Dept. of Food Science and Technology, Chonnam National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.5, 2005 , pp. 632-637 More about this Journal
Abstract
This study has been carried out to understand the effect of Hovenia dulcis on the hyperglycemic mice induced with streptozotocin (STZ). Mice in control group were administered with $0.9\%$ saline (2 mL/kg), and experimental groups were administered Hovenia dulcis extract (H1 group, 0.01 g/kg: H2 group, 0.04 g/kg) after hyperglycemic state was induced. Blood glucose concentrations of tile H1 and H2 groups administered with Hovenia dulcis extract for 6 weeks were significantly (p<0.01), compared to control group. Blood glucose tolerance was more favorable in H1 and H2 groups than control group. The Langerhan's islet of pancreas was destructed by treatment of STZ in the control group, but pancreatic islet of the experimental groups was partially recovered from damage, and a number of insulin-positive cells were observed. A number of insulin-like growth factor- I and II (IGF-I and IGF-II) positive cells occurred in the acinar cells of H1 and H2 groups. These results suggest that administration of Hovenia dulcis extract help mice recover from the damage induced with STZ.
Keywords
Hovenia dulcis; hyperglycemic mice; insulin; IGF;
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