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http://dx.doi.org/10.3746/jkfn.2005.34.3.317

Study on the Anti-tumor Effects of Extracts from Lepista nuda Mushroom  

Lee, Yang-Suk (Dept. of Herbal Biotechnology, Daegu Haany University)
Han, Joo-Young (Dept. of Food Cuisine and Nutrition, Daegu Haany University)
Joo, Eun-Yong (Dept. of Herbal Biotechnology, Daegu Haany University)
Shin, Seung-Ryeul (Dept. of Food Cuisine and Nutrition, Daegu Haany University)
Kim, Nam-Woo (Dept. of Herbal Biotechnology, Daegu Haany University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.3, 2005 , pp. 317-322 More about this Journal
Abstract
This study was carried to investigate the inhibition effects of Lepista nuda mushroom extracts on the growth of the human cancer (HepG2, KATOⅢ, AGS) cells. The fraction Ⅰ of Lepista nuda mushroom extracts strongly inhibited to 71.4-91.8% for the growth of cancer cells. The growth of cancer HepG2, KATOⅢ and AGS cell which treated with 0.5 and 1㎎/mL of hot water fraction I was inhibited to 71.4% and 85.5%, 45.0% and 86.6%, 71.6% and 90.7% respectively. The growth of cancer cell HepG2, KATOⅢ and AGS which treated with 0.5 and 1㎎/mL of microwave fraction I was inhibited to 79.8% and 85.2%, 78.6% and 88.9%, 85.8% and 91.8%, respectively. The inhibition ratios of cancer cell growth were higher by microwave extracts than hot water extracts. And the more fraction were insoluble for water, the more inhibition ratios of cancer cell growth were lower.
Keywords
mushroom; Lepista nuda; anti tumor; cancer; extract;
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1 Jeong OJ, Yoon HS, Min YK. 2001. Aroma characteristics of Neungee. Korean J Food Sci Technol 33: 307-312
2 Ma SJ. 1983. Effects of the substances extracted from dried mushroom by several organic solvents on the stability of fat. J Food Sci 15: 150-154
3 Chang ST, Hayes WA. 1990. The biology and cultivation of edible mushrooms. Academic Press, New York
4 Kabir Y, Kimura S. 1989. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats. J Nutr Sci Vitaminol 35: 91-94   DOI
5 Dennert G, Tucker D. 1973. Antitumor polysaccharide lentina a T cell adjuvant. J Natl Cancer Inst 51: 1727-1735   DOI
6 Kim HJ, Han J. Yang EJ, Lee KR, Lee IS. 2000. Chemoprevention effect of Polyozellus multiplex, a wild and edible mushroom. J Korean Soc Food Sci Nutr 29: 161-167
7 Hamuro G, Wagner H. 1978. $\beta$-1,3 glucan mediated augmentation of alloreactive murine cytotoxic T lymphocytes in vivo. Cancer Res 38: 3080-3088
8 Kim HK, Kwon YJ, Kwak HJ, Kwon JH. 1999. Oleoresin content and functional characteristic of fresh garlic. Korean J Food Sci Technol 31: 329-335
9 Lee SB, Lee GD, Kwon JH. 1999. Optimization of extraction conditions for soluble ginseng compounds using microwave extraction system under pressure. J Korean Soc Food Sci Nutr 28: 409-416
10 McConnell JEW, Esselen WB Jr. 1947. Carbohydrates in cultivated mushrooms. Food Res 12: 118-152   DOI
11 Zakia-Bano S. 1988. Raj arathnam, Pleurotus mushrooms. Part II. Chemical composition, nutritional value, postharvest physiology, preservation, and role as human food. CRC Rev Food Sci Nutr 27: 87-158   DOI   ScienceOn
12 Hong JS, Kim YH, Kim MK, Kim YS, Sohn HS. 1989. Contents of free amino acids and total amino acids in Agaricus blsporus, Pleurotus ostreatus and Leniinus edodes. J Food Sci 21: 58-62
13 Chang ST, Miles PC. 1989. Edible mushroom and their cultivation. CRC Press, New York
14 Yang KH, Yang JH, Ryu BH. 1997. Antitumor effects of extracts obtained from Daedalea dickinsii. Kor J Appl Microbiol Biotechnol 25: 178-182
15 Yoon SH, Lim JH, Kim YS, Kim CH, Jo JH, Hwang YS. 1998. Pharmacological effects of proteoglycans extracted from fruiting bodies of Fomitellafraxinea. Korea J Mycol 26: 511-518
16 Zhang J, Wang G, Li H, Zhuang C, Mizuno T, Ito H, Suzuki C, Okamoto H, Li J. 1994. Antitumor polysaccharides from a chinese mushroom 'Yuhuangrno', the fruiting body of Pleurotus citrinopileatus. Bioci Biotech Biochem 58: 1195-1201   DOI   ScienceOn
17 Chung SY, Kim SH, Kim HS, Kang JS, Cheong HS, Kim CJ, Kim HJ. 1990. Effects of water soluble extract of Ganoderma lucidum, kale juice and sodium dextrothyroxine on hormone and lipid metabolism in hypercholesterolemic rats I. Concentrations of triodothyronine, thyroxine, blood sugar and lipid composition in serum. J Korean Soc Food Sci Nutr 19: 381-386
18 Mizuno T, Ohsawa K, Hagiware N, Kuboyama R. 1986. Fractionation and characterization of antitumor polysaccharides from Maitake, Grijola frondosa. Agric Biol Chem 50: 1679-1688   DOI
19 Lee JW, Chung CH, Jeoung HJ, Lee KH. 1990. Anticomplementary and antitumor activities of the ikal. extract from the mycelia of Lentinus edodes IY -105. Korean J Appl Microbiol Biotechnol 18: 571-577
20 Park SS, Lee KD, Min TJ. 1995. Study on the screening and development of antibiotics in the mushrooms. Korean J Mycol 23: 28-36
21 Yoshikumi C, Nomoto K, Matsunaga K, Fujii T, Takeya K. 1975. Mouse strain difference in the expression of antitumor activity of PS- K. Gann 66: 649-654
22 Park DW, Shim MHJ, Kim BK. 1979. Studies on constituents of higher fungi of Korea (XVII). Production of antintoplastic components by the submerged culture of Lentinus edodes. Seoul Univ J Pharm Sci 4: 19-26
23 Sung JM, Yoo YB, Cha DY. 1998. Mushroom Science. Kyo- Hak Publ, Seoul, Korea
24 水野 卓, 川合正允 1992. きのこの化學, 生物學, 學會出版セイタ, 東京, 日本
25 Woo MJ. 1983. Studies on antitumor Components of Flammulina velutipes of Korea (II). Korean J Mycol 11: 147-150
26 左藤恵理, 淸柳康夫, 管原龍幸 1985. キノユ類の遊離ァにキ ノ酸組成について. 日本食品工業學會誌 32: 509-513
27 Wallace PK, Morahan PS. 1994. Role of macrophages in the immunotherapy of lewis lung peritoneal carcinomatosis. J Leukoc Biol 56: 41-51
28 Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, Yadomae T. 1984. Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa. J Pharm Dyn 7: 492-550   DOI
29 Park WH. 1998. Studies on inorganic components of Korean wild edible mushrooms-Trace mineral elements of Armillariella mella, Hygrophorous russula, Armillariella tabescens, Lepista nuda, Leoista sordida, Hygrocybe conica. Korea J Mycol 21: 273-278
30 Park WH, Lee HD. 1999. Illustrated book of Korean medicinal mushrooms. Kyo- Hak Publishing Co., Ltd., Seoul, Korea. p 186
31 Kim JH, Yoo KH, Kim YS, Seok SJ, Kim YS. 1998. The screening of fibrinolytic activities of extracts from mushrooms in mt. Chiak. Korea J Mucol 26: 589-593
32 Shim SM. 2003. Studies on immumo-modulatory and antitumor effects of crude polysaccharides extracted from Korean wild medicinal mushrooms. PhM Thesis. Inchon Univ
33 Ohino N, Miura NN, Nakajima N, Yadomae T. 2000. Antitumor 1,3-glucan from cultured fruit body of Sparassis crispa. Bio Pharm Bull 23: 866-872   DOI   ScienceOn
34 Pare JRJ, Belanger JMR, Stafford MR. 1994. Microwave-assisted process; a new tool for the analytical laboratory. Trends in Analytical Chemistry 13: 176-184   DOI   ScienceOn
35 Green LM, Reade JL, Ware CF. 1984. Rapid colometric assay for cell viability: Application to the quantitation of cytotoxic and growth inhibitory lympokines. J Immunol Meth 70: 257-268   DOI   ScienceOn
36 Ji JH, Kim MN, Choi KP, Chung CK, Ham SS. 2000. Antimutagenic and cytotoxicity effects of Agaricus blazei Murill extracts. Korean J Food Sci Technol 32: 1371-1378