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http://dx.doi.org/10.3746/jkfn.2005.34.1.021

Antioxidative Effects and Its Metabolites in Rat Fed Sesamol  

Lee, Min-Sun (호서대학교 벤처전문대학원 첨단산업기술학과)
Kim, Hyeon-We ((주) 오뚜기 중앙 연구소)
Bang, Sun-Kwon (호서대학교 자연과학부 생명과학전공)
Kang, Myung-Hwa (호서대학교 벤처전문대학원 첨단산업기술학과, 호서대학교 식품영양학과)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.1, 2005 , pp. 21-26 More about this Journal
Abstract
Although the sesame lignans, sesamol, have been shown to possess antioxidative activity, less is known about the metabolism and antioxidative properties of sesamol, a major constituent of sesame oil. To determine the ability of sesamol to act as an antioxidant in vivo, we fed rats a diet containing 0.5% sesamol for 3 wk and studied its metabolism and its effects on oxidative stress. Body weight gain and weight of liver, kidneys were significantly higher in the rats fed sesamol than in rats fed the control diets. GST and GST-Px activities in rat liver microsomes were higher in rats fed sesamol and CAT activities were found to be significantly increased in rats fed sesamol. The formation of TBARS was decreased in the liver of rat fed the 0.5% sesamol diet than in controls. We detected sesamol metabolites in liver and kidneys of rats fed sesamol and its metabolites were present as conjugated glucuronides and sulfates. In contrast, not detected sesamol peak in other organs such as colon, small intestine and pancreas.
Keywords
sesamol; antioxidants; metabolites; rats;
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