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http://dx.doi.org/10.3746/jkfn.2005.34.10.1531

Effects of Cordyceps militaris on Key Enzymes of Carbohydrate Metabolism  

Kim, Hyun-Sook (Korea Institute Nutritional Science, Kangwon National University)
Ro, Young-Joo (Dept. of Food Science and Technology in Animal Resources, Kangwon National University)
Choe, Myeon (Dept. of Food Science and Technology in Animal Resources, Kangwon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.10, 2005 , pp. 1531-1535 More about this Journal
Abstract
The present study was designed to investigate the antidiabetic effect of Cordyceps militaris on activities of hepatic glucose-regulating enzymes, such as glucokinase (GK), pyruvate dehydrogenase (PDH) and acetyI-CoA carboxylase (ACC). We have isolated the active compounds, CM-A and CM-B from C. militaris and the extracts are under investigation to determine their mechanism of action. Hepatic GK, PDH and ACC activities were significantly (p < 0.05) increased compared with the control. Treatment with CM-A led to a rise in percentage of enzymes by 380$\%$,396$\%$ and 286$\%$, respectively, relative to control levels. CM-B were 329$\%$, 312$\%$ and 239$\%$, respectively. The increase in GK and ACC activities was linearly proportional with increased ratio of CM-A. Our findings suggest that C. militaris exerted antihyperglycemic potency, which is thought to be mediated through activation of GK, PDH and ACC enzymes related to glucose metabolism directly or indirectly and therefore C. militaris is promising as antidiabetic functional foods.
Keywords
Cordyceps militaris; antihyperglycemic; glucokinase; pyruvate dehydrogenase; acetyl-CoA carboxylase;
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