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http://dx.doi.org/10.3746/jkfn.2005.34.10.1520

Antitumor Effect of Young Radish Kimchi Prepared with Young Radish Cultivated in the Soil Containing Sulfur on Sarcoma-180 Tumor Cells Transplanted Mice  

Kong, Chang-Suk (Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University)
Bak, Soon-Sun (Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University)
Rhee, Sook-Hee (Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University)
Kil, Jeung-Ha (Department of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University)
Rho, Chi-Woong (Research Center for Exportable Agricultural Crops (RCEC), Gyeongsangnam-do Agricultural Research & Extension Services)
Hwang, Hae-Jun (Research Center for Exportable Agricultural Crops (RCEC), Gyeongsangnam-do Agricultural Research & Extension Services)
Kim, Nak-Ku (Research Center for Exportable Agricultural Crops (RCEC), Gyeongsangnam-do Agricultural Research & Extension Services)
Park, Kun-Young (Research Center for Exportable Agricultural Crops (RCEC), Gyeongsangnam-do Agricultural Research & Extension Services)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.10, 2005 , pp. 1520-1524 More about this Journal
Abstract
Young radishes (YR, yeolmu in Korean) were cultivated in the soil with and without sulfur. Young radish kimchi-general (YR kimchi-G) was prepared with YR commonly cultivated in the soil without sulfur. Young radish kimchl-sulfur (YR kimchi-S) and young radish kimchi-sulfur with lime mortar (YR kimchi-SL) were prepared with the YR cultivated in the soil with sulfur an4 sulfur added lime mortar on it respectively. Antitumor effects of methanol extracts from the YR kimchis were investigated in sarcoma-180 tumor cell transplanted mice. The solid tumor growth was significantly inhibited by the YR kimchi-SL prepared with YR grown in the soil with sulfur (p < 0.05). The treatment of the methanol extracts from YR kimchi-S and -SL increased the glutathione S-transferase activities and glutathione contents in the livers, compared to thlose of YR kimchi-G and the control. One of the antitumor effects by the YR kimchis was due to the increased the glutathione levels and the glutathione S-transferase activity which is phase 2 enzyme. These results also suggested that the antitumor effects of YR kimchi can be enhanced by using YR cultivated differently in the presence of sulfur that can help to produce sulfur-containing compounds in YR.
Keywords
young radish kimchi; sulfur; antitumor effect; sarcoma-180 cell;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Korea Institute for Health & Social Affairs. 1989. Food and Nutrient Databases and Dietary Guidance. 5th ed
2 National Rural Living Science Institute, RDA. 1996. Food composition table. 5th ed
3 Alegria BC. 1992. Cancer-preventive foods and ingredients. Food Technology 46: 65-68
4 Kim GE, Lee YS, Kim SH, Cheong HS, Lee JH. 1998. Changes of chlorophyll and their derivative contents during storage of Chinese cabbage, leafy radish and leaf mustard kimchi. J Korean Soc Food Sci Nutr 27: 852-857
5 Endo Y, Usuki R, Kaneda T. 1984. Prooxidant activities of chlorophylls and their decomposition products on the photoxidation of methyl linoleate. JAOCS 61: 781-784   DOI
6 Endo Y, Usuki R, Kaneda T. 1985. Antioxidant effects of chlorophyll and pheophytin on the autoxidation of oil in the dark, I. Comparison of the inhibitory effects. JAOCS 62: 1375-1378   DOI
7 Endo Y, Usuki R, Kaneda T. 1985. Antioxidant effects of chlorophyll and pheophytin on the autoxidation of oil in the dark, II. The mechanism of antioxidant action chlorophyll effects. JAOCS 62: 1387-1390   DOI
8 Tan YA, Chong CL, Low KS. 1997. Crude palm oil characteristics and chlorophyll content. J Sci Food Agric 75: 281-288   DOI   ScienceOn
9 Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P. 2002. Direct evidence that sulfhydryl groups of Keapl are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Amd Sci USA 99: 11908-11913
10 Fahey JW, Zhang Y, Talalay P. 1997. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci USA 94: 10367-10372
11 Ellaman GL. 1959. Tissue sulfhydryl group. Arch Biochem Biophys 82: 70-72   DOI   ScienceOn
12 Lowry OH, Rosebrough NH, Farr AL, Randall RJ. 1951. Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275
13 Choi MW, Kim KY, Park KY. 1997. Effects of kimchi extracts on the growth of sarcoma-180 cells and phagocytic activity of mice. J Korean Soc Food Sci Nutr 26: 254-260
14 Gentile JM, Gentile GJ, 1991. The metabolic activation of 4-nitro-o-phenylenediamine by chlorophyll containing plant extracts: The relationship between mutagenicity and anti- mutagenicity. Mutation Res 250: 79-86   DOI   ScienceOn
15 Kim IH. 1989. New Medicine. Kwangjaewon, Seoul. p 80-81
16 Elizabeth KL, Tracy KS, Rosemary GC, Ian TJ. 2001. Cell death in the colorectal cancer cell line HT29 in response to glucosinolate metabolites. J Sci Food Agric 81: 959-961   DOI   ScienceOn
17 Faukner K, Mithen R, Williamson G. 1998. Selective increase of the potential anticarcinogen 4-methylsulphinyl-butyl glucosinolate in broccoli. Carcinogenesis 19: 605-609   DOI   ScienceOn
18 Kim KA, Rho CW, Choi KR, Hwang HJ, Choi RS. 2004. Quinone reductase inducer from radish leaf cultivated in the soil containing sulfur. J Korean Soc Food Sci Nutr 33: 946-950   DOI   ScienceOn
19 Lee YS, Kim DS, Ryu BH, Lee SH. 1992. Antitumor and immunomodulating effects of seaweeds toward sarcoma180 cell. J Korean Soc Food Nutr 21: 544-550
20 Agricultural R&D Promotion Center. 2005. Commercialization and technical development of functional young radish kimchi. 2st Annual Report
21 Habig WH, Pabist MJ, Jakoby WB. 1974. Glutathione S-transferase. The first step in mercapturate acid formation. J Biol Chem 249: 7130-7139
22 Wim AN, Marinka AB, Martijin HS, Wilbert HM. 1995. Enhancement of rat hepatic and gastointestinal glutathione and glutathione s-transferase by $\alpha$-angelicalactone and flavone. Carcinogenesis 16: 607-612   DOI   ScienceOn
23 Burk RF, Trumble MJ, Lawerence RA. 1980. Rat hepatic cytosolic glutathione dependent enzyme protection against lipid peroxidation in the NADPH -microsomal lipid peroxidation system. Biochem Biophys Acta 618: 35-41   DOI   ScienceOn
24 Meister A, Anderson ME. 1983. Glutathione. Annu Rev Biochem 52: 711-716   DOI   ScienceOn
25 Zhang Y, Talalay P, Cho CG, Postner GH. 1992. A major inducer of anticancarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 89: 2399-2430
26 Zhang Y, Kensler TW, Cho CG, Postner GH, Talalay P. 1994. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbomyl isothiocyanates. Proc Natl Amd Sci USA 91: 3147-3150
27 Fahey JW, Haristory X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Iozniewski A. 2002. soiforaphane inhibits extracellular, intracellular, antibioticresistant strains of Helicobacter pyroli and prevents benzopyrene-induced stomach tumors. Proc Natl Acad Sci USA 99: 7610-7615