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http://dx.doi.org/10.3746/jkfn.2005.34.10.1503

Production of NO, TNF-α and IL-6 by Squalene, Alkoxy Glycerol, Batyl and Chimyl Solutions in RAW 264.7 Macrophage Cells  

Kim, Young-Ho (College of Pharmacy, Research Institute of Drug Development Chonnam University, Dept of Natural Science, Biology, Chosun University)
Yoon, Hyun-Joong (College of Pharmacy, Research Institute of Drug Development Chonnam University)
Moon, Myoung-E (College of Pharmacy, Research Institute of Drug Development Chonnam University)
Lee, Jun-Haeng (Dept of Natural Science, Biology, Chosun University, Dept of Radiological Science, Nambu University)
Park, Haeng-Soon (College of Pharmacy, Research Institute of Drug Development Chonnam University)
Kim, Jong-Se (Dept of Natural Science, Biology, Chosun University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.34, no.10, 2005 , pp. 1503-1508 More about this Journal
Abstract
The purpose of the present study was to evaluate the effect of Squalene, Alkoxy Glycerol, Batyl and Chimyl solutions on the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF- $\alpha$ ) and interleukin-6 (IL-6) in RAW 264.7 macrophage cells after treatment of C.albicans. The cytotoxic effects was evaluated by the lactate dehydrogenase (LDH). All solutions did not affect on the LDH and NO production by itself. At 6th hour, the TNF- $\alpha$ and IL-6 production was not affected by each solutions. However, at 24th hour, the TNF- $\alpha$ and IL-6 production was affected by itself (p < 0.05). Each solution in the presence of C. albicans decreased the C. albicans-induced TNF- $\alpha$ and IL-6 production compared with C. albicans only (p < 0.05, p < 0.01). These results suggest that Squalene, Alkoxy Glycerol, Batyl and Chimyl solutions will increase the immune response on the C. albicans-induced damage.
Keywords
IL-6; NO; LDH; C. albicans; Squalene; Alkoky Glycerol;
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