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http://dx.doi.org/10.3746/jkfn.2004.33.9.1439

Anticancer and Immuno - Activity of Onion Kimchi Methanol Extract  

Park, Kyung-Uk (Dept. of Food and Nutrition, Sunchon National University)
Kim, Jae-Yong (Research Institute of Basic Science, Sunchon National University)
Cho, Young-Sook (Dept. of Food and Nutrition, Sunchon National University)
Lee, Sung-Tae (Dept. to Biology, Sunchon National University)
Jeong, Chang-Ho (Dept. of Applied Life Sciences, Graduate School, Gyeongsang National University)
Kang, Kap-Suk (Group Dept. of Leisure Industry, Pusan Information and Technology College)
Seo, Kwon-Il (Dept. of Food and Nutrition, Sunchon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.33, no.9, 2004 , pp. 1439-1444 More about this Journal
Abstract
Antitumor activities of onion methanol extract (OME) and onion Kimchi methanol extract (OKME) were investigated by using aflatoxin $B_1$-mediated Salmonella typhimurium mutagenicity and the model of cytotoxicity on the cancer cell lines. Their immune activities were also investigated by using mouse spleen cells and macrophage cell lines, respectively. OME and OKME showed the enhanced antimutagenicity in a dose-dependent manner in particular, the activity of OKME was higher than that of OME. OME and OKME decreased over 20% of the proliferation of the A549 (lung cancer cell) and MCF-7 (breast cancer cell) cell lines when compared with the control at 1,000 ${\mu}$g/mL. The proliferation of mouse spleen cells and the NO production in marcrophage cell lines treated OME and OKME were increased in a dose-dependent manner compared with untreated control cells, and their activities of OKME were higher than those of OME.
Keywords
onion; onion Kimchi; anticancer activity; immuno-activity;
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Times Cited By KSCI : 1  (Citation Analysis)
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