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http://dx.doi.org/10.3746/jkfn.2004.33.7.1133

Effect of Rhemanniae Radix on the Hyperglycemic Mice Induced with Streptozotocin  

김정상 (동신대학교 한의과대학)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.33, no.7, 2004 , pp. 1133-1138 More about this Journal
Abstract
This study has been carried out to investigate the effect of the administration of Rhemanniae Radix extract (5.0 mL/kg/day, RR group) on the hyperglycemic mice (HM group) induced with streptozotocin (STZ). In blood glucose level, RR group showed a significant decrease compared with HM group. The result of glucose tolerance test was more favorable in RR than HM group. A lot of insulin-positive cells and insulin-like growth factor-II positive materials were observed in RR group. A number of apoptotic particles were observed in the HM group, but several apoptotic nuclei were found in RR group. Pancreatic islets of HM group were destructed by the administration of STZ, but islets were recovered from damage in the RR group. These results suggest that administration of Rhemanniae Radix extract to the hyperglycemic mice prevent from the damage induced by STZ.
Keywords
Rhemanniae Radix; hyperglycemic mice; insulin-positive cells; insulin-like growth factor-II; apoptosis;
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Times Cited By KSCI : 1  (Citation Analysis)
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